RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the CytR regulatory interaction in cdd orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for cdd was scanned with the annotated matrix for CytR. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitescdd_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_CytR_sites.tab
Ortholog predicted binding sites graphcdd_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_CytR_sites.jpg
genescdd_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencecdd_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
Orthologscdd_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencescdd_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencescdd_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigcdd_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_CytR_occ_sig.tab
Occ sig graphcdd_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_CytR_occ_sig.jpg
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Occ freq graphcdd_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_CytR_occ_freq.jpg
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