RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the CytR regulatory interaction in tsx orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for tsx was scanned with the annotated matrix for CytR. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitestsx_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_CytR_sites.tab
Ortholog predicted binding sites graphtsx_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_CytR_sites.jpg
genestsx_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencetsx_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
Orthologstsx_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencestsx_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencestsx_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigtsx_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_CytR_occ_sig.tab
Occ sig graphtsx_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_CytR_occ_sig.jpg
(Click on image below)
Occ freq graphtsx_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_CytR_occ_freq.jpg
(Click on image below)
RegulonDB