RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the FadR regulatory interaction in fabA orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for fabA was scanned with the annotated matrix for FadR. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitesfabA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_sites.tab
Ortholog predicted binding sites graphfabA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_sites.jpg
genesfabA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencefabA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologsfabA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencesfabA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencesfabA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigfabA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_occ_sig.tab
Occ sig graphfabA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_occ_sig.jpg
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Occ freq graphfabA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_occ_freq.jpg
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