RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the FadR regulatory interaction in fabB orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for fabB was scanned with the annotated matrix for FadR. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitesfabB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_sites.tab
Ortholog predicted binding sites graphfabB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_sites.jpg
genesfabB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencefabB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologsfabB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencesfabB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencesfabB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigfabB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_occ_sig.tab
Occ sig graphfabB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_occ_sig.jpg
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Occ freq graphfabB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_occ_freq.jpg
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