RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the FadR regulatory interaction in fadB orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for fadB was scanned with the annotated matrix for FadR. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitesfadB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_sites.tab
Ortholog predicted binding sites graphfadB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_sites.jpg
genesfadB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencefadB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologsfadB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencesfadB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencesfadB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigfadB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_occ_sig.tab
Occ sig graphfadB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_occ_sig.jpg
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Occ freq graphfadB_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_occ_freq.jpg
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