RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the FadR regulatory interaction in iclR orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for iclR was scanned with the annotated matrix for FadR. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitesiclR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_sites.tab
Ortholog predicted binding sites graphiclR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_sites.jpg
genesiclR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequenceiclR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologsiclR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencesiclR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencesiclR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigiclR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_occ_sig.tab
Occ sig graphiclR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_occ_sig.jpg
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Occ freq graphiclR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_FadR_occ_freq.jpg
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