RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the PdhR regulatory interaction in glcD orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for glcD was scanned with the annotated matrix for PdhR. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitesglcD_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_PdhR_sites.tab
Ortholog predicted binding sites graphglcD_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_PdhR_sites.jpg
genesglcD_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequenceglcD_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologsglcD_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencesglcD_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencesglcD_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigglcD_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_PdhR_occ_sig.tab
Occ sig graphglcD_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_PdhR_occ_sig.jpg
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Occ freq graphglcD_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_PdhR_occ_freq.jpg
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