RegulonDB Summary of evolutionary conservation

Summary of evolutionary conservation of PurR gene regulated (first gene of a TU) interactions

Evolutionary conservation in RegulonDB is limited to gammaproteobacteria. Conservation of a regulatory interaction, i.e. a TF regulating a target gene, is inferred from the overrepresentation of TFBSs in upstream regions of the orthologous target genes. We searched for TFBS conservation only in those genomes with an ortholog for the TF and for the regulated gene. Orthologs were selected based on a bidirectional best-hit procedure using RSAT tools package. Overrepresentation is calculated based on the binomial distribution; the binomial significance is shown in following table as significance of conservation.

First Gene Significance of conservation (nd) Footprint conservation
carA 34.21
codB 29.13
cvpA 15.10
gcvT 42.99
glnB nd
glyA 45.72
guaB 15.73
hflD 0 (Below threshold)
prs nd
purA 12.44
purC 53.41
purE 157.34
purH 42.67
purL 103.13
purM 91.83
purR 34.57
pyrC 15.92
pyrD 60.19
speA 2.32 (Below threshold)