RegulonDB Summary of evolutionary conservation

Summary of evolutionary conservation of RcsB gene regulated (first gene of a TU) interactions

Evolutionary conservation in RegulonDB is limited to gammaproteobacteria. Conservation of a regulatory interaction, i.e. a TF regulating a target gene, is inferred from the overrepresentation of TFBSs in upstream regions of the orthologous target genes. We searched for TFBS conservation only in those genomes with an ortholog for the TF and for the regulated gene. Orthologs were selected based on a bidirectional best-hit procedure using RSAT tools package. Overrepresentation is calculated based on the binomial distribution; the binomial significance is shown in following table as significance of conservation.

First Gene Significance of conservation (nd) Footprint conservation
bdm 2.72 (Below threshold)
bglG nd
csgD nd
flhD nd
ftsA nd
gadA nd
gadB 0 (Below threshold)
gadY nd
hdeA 0 (Below threshold)
hdeD 0 (Below threshold)
leuO nd
osmB nd
osmC 0.26 (Below threshold)
rcsA nd
rprA nd
safA 0 (Below threshold)
wza nd
ydeP -2.46 (Below threshold)
yjbE nd