RegulonDB RegulonDB 11.0: Gene Form
   

cadC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

cadC cadB yjdQ pheU MlrA FNR H-NS H-NS ArcA H-NS H-NS H-NS cadCp cadCp cadBp cadBp

Gene      
Name: cadC    Texpresso search in the literature
Synonym(s): ECK4127, EG10133, b4133
Genome position(nucleotides): 4360396 <-- 4361934
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 41.98
External database links:  
ASAP:
 ABE-0013532
CGSC:
 34231
ECHOBASE:
 EB0131
ECOLIHUB:
 cadC
OU-MICROARRAY:
 b4133
STRING:
 511145.b4133
COLOMBOS: cadC


Product      
Name: DNA-binding transcriptional activator CadC
Synonym(s): CadC
Sequence: Get amino acid sequence Fasta Format
Regulator Family: OmpR
Cellular location: cytosol,inner membrane
Molecular weight: 57.813
Isoelectric point: 5.499
Motif(s):
 
Type Positions Sequence Comment
3 -> 102 QPVVRVGEWLVTPSINQISRNGRQLTLEPRLIDLLVFFAQHSGEVLSRDELIDNVWKRSIVTNHVVTQSISELRKSLKDNDEDSPVYIATVPKRGYKLMV UniProt: OmpR/PhoB-type.
24 -> 100 GRQLTLEPRLIDLLVFFAQHSGEVLSRDELIDNVWKRSIVTNHVVTQSISELRKSLKDNDEDSPVYIATVPKRGYKL
120 -> 124 PPPIP UniProt: Significantly reduced dependence on EF-P for translation, increased levels of protein in an efp-strain..
121 -> 121 P UniProt: Reduced dependence on EF-P for translation, increased levels of protein in an efp- strain..
155 -> 180 RFTTFWVWFFFLLSLGICVALVAFSS UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.3 - amino acids
  2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
  3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.2 - activator
  3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
GO:0032993 - protein-DNA complex
molecular_function GO:0003677 - DNA binding
GO:0005515 - protein binding
GO:0000156 - phosphorelay response regulator activity
GO:0042803 - protein homodimerization activity
GO:0000976 - transcription cis-regulatory region binding
GO:0001216 - DNA-binding transcription activator activity
biological_process GO:0006355 - regulation of transcription, DNA-templated
GO:0045893 - positive regulation of transcription, DNA-templated
GO:0000160 - phosphorelay signal transduction system
Note(s): Note(s): ...[more].
Evidence: [IMP] Inferred from mutant phenotype
Reference(s): [1] Dell CL., et al., 1994
[2] Tetsch L., et al., 2008
[3] Watson N., et al., 1992
External database links:  
ALPHAFOLD:
 P23890
DIP:
 DIP-9239N
ECOCYC:
 PD00436
ECOLIWIKI:
 b4133
INTERPRO:
 IPR001867
INTERPRO:
 IPR011990
INTERPRO:
 IPR036388
INTERPRO:
 IPR040970
INTERPRO:
 IPR039420
INTERPRO:
 IPR016032
MODBASE:
 P23890
PANTHER:
 PTHR48111
PDB:
 3LY8
PDB:
 3LYA
PDB:
 5JU7
PDB:
 3LY9
PDB:
 3LY7
PFAM:
 PF00486
PFAM:
 PF18500
PRIDE:
 P23890
PROSITE:
 PS51755
REFSEQ:
 NP_418557
SMART:
 SM00862
SMR:
 P23890
UNIPROT:
 P23890


Operon      
Name: cadC         
Operon arrangement:
Transcription unit        Promoter
cadC


Transcriptional Regulation      
Display Regulation             
Activated by: FNR, CadC, MlrA
Repressed by: LeuO, OmpR, H-NS


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Dell CL., Neely MN., Olson ER., 1994, Altered pH and lysine signalling mutants of cadC, a gene encoding a membrane-bound transcriptional activator of the Escherichia coli cadBA operon., Mol Microbiol 14(1):7-16

 [2] Tetsch L., Koller C., Haneburger I., Jung K., 2008, The membrane-integrated transcriptional activator CadC of Escherichia coli senses lysine indirectly via the interaction with the lysine permease LysP., Mol Microbiol 67(3):570-83

 [3] Watson N., Dunyak DS., Rosey EL., Slonczewski JL., Olson ER., 1992, Identification of elements involved in transcriptional regulation of the Escherichia coli cad operon by external pH., J Bacteriol 174(2):530-40

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