RegulonDB RegulonDB 10.9: Gene Form
   

clpX gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

clpX clpP sraA terminator anti-terminator anti-anti-terminator TSS_585 TSS_585 TSS_584 TSS_584 TSS_583 TSS_583 TSS_582 TSS_582 TSS_581 TSS_581 TSS_580 TSS_580 clpXp clpXp TSS_578 TSS_578 TSS_577 (cluster) TSS_577 (cluster) TSS_576 TSS_576

Gene      
Name: clpX    Texpresso search in the literature
Synonym(s): ECK0432, EG10159, b0438, lopC
Genome position(nucleotides): 457426 --> 458700 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.53
External database links:  
ASAP:
ABE-0001517
CGSC:
31287
ECHOBASE:
EB0157
ECOLIHUB:
clpX
OU-MICROARRAY:
b0438
STRING:
511145.b0438
COLOMBOS: clpX


Product      
Name: ATP-dependent Clp protease ATP-binding subunit ClpX
Synonym(s): ClpX, LopC
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 46.356
Isoelectric point: 5.003
Motif(s):
 
Type Positions Sequence
268 -> 274 IGFGATV
315 -> 318 NELS
317 -> 395 LSEEALIQILKEPKNALTKQYQALFNLEGVDLEFRDEALDAIAKKAMARKTGARGLRSIVEAALLDTMYDLPSMEDVEK
228 -> 230 RKH
370 -> 370 R

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.3 - proteins/peptides/glycopeptides
  2 - information transfer --> 2.3 - protein related --> 2.3.4 - chaperoning, repair (refolding)
  2 - information transfer --> 2.3 - protein related --> 2.3.6 - turnover, degradation
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0009376 - HslUV protease complex
molecular_function GO:0097718 - disordered domain specific binding
GO:0002020 - protease binding
GO:0005515 - protein binding
GO:0016887 - ATPase activity
GO:0046872 - metal ion binding
GO:0051082 - unfolded protein binding
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0004176 - ATP-dependent peptidase activity
GO:0008270 - zinc ion binding
GO:0042802 - identical protein binding
GO:0046983 - protein dimerization activity
biological_process GO:0030164 - protein denaturation
GO:0051301 - cell division
GO:0006457 - protein folding
GO:0006508 - proteolysis
GO:0030163 - protein catabolic process
GO:0016032 - viral process
GO:0043335 - protein unfolding
External database links:  
DIP:
DIP-35907N
ECOCYC:
EG10159-MONOMER
ECOLIWIKI:
b0438
INTERPRO:
IPR038366
INTERPRO:
IPR027417
INTERPRO:
IPR010603
INTERPRO:
IPR019489
INTERPRO:
IPR003593
INTERPRO:
IPR003959
INTERPRO:
IPR004487
MODBASE:
P0A6H1
PANTHER:
PTHR11262
PDB:
2DS6
PDB:
4I9K
PDB:
4I81
PDB:
4I63
PDB:
4I5O
PDB:
4I4L
PDB:
4I34
PDB:
3HWS
PDB:
3HTE
PDB:
2DS8
PDB:
2DS7
PDB:
2DS5
PDB:
1OVX
PFAM:
PF06689
PFAM:
PF10431
PFAM:
PF07724
PRIDE:
P0A6H1
PRODB:
PRO_000022300
PROSITE:
PS51902
REFSEQ:
NP_414972
SMART:
SM00382
SMART:
SM00994
SMART:
SM01086
SMR:
P0A6H1
SWISSMODEL:
P0A6H1
UNIPROT:
P0A6H1


Operon      
Name: clpPX-lon         
Operon arrangement:
Transcription unit        Promoter
clpPX
clpPX
clpPX
clpX-lon
lon
lon


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_576 457052 forward nd [RS-EPT-CBR] [1]
  promoter TSS_577 (cluster) 457151 forward For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_578 457171 forward nd [RS-EPT-CBR] [1]
  promoter TSS_580 457296 forward nd [RS-EPT-CBR] [1]
  promoter TSS_581 458066 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_582 458197 forward nd [RS-EPT-CBR] [1]
  promoter TSS_583 458293 forward nd [RS-EPT-CBR] [1]
  promoter TSS_584 458768 forward nd [RS-EPT-CBR] [1]
  promoter TSS_585 458780 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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