RegulonDB RegulonDB 10.8: Gene Form
   

grpE gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yfjD nadK grpE CRP terminator anti-terminator anti-anti-terminator terminator nadKp2 nadKp2 grpEp grpEp TSS_2962 TSS_2962

Gene      
Name: grpE    Texpresso search in the literature
Synonym(s): ECK2610, EG10416, b2614
Genome position(nucleotides): 2750115 <-- 2750708 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
50.34
External database links:  
ASAP:
ABE-0008598
CGSC:
660
ECHOBASE:
EB0411
OU-MICROARRAY:
b2614
PortEco:
grpE
STRING:
511145.b2614
COLOMBOS: grpE


Product      
Name: nucleotide exchange factor GrpE
Synonym(s): GrpE, heat shock protein GrpE
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 21.798
Isoelectric point: 4.393
Motif(s):
 
Type Positions Sequence
82 -> 82 K
102 -> 102 L
117 -> 137 SAMVEGIELTLKSMLDVVRKF
127 -> 127 L
174 -> 174 M

 

Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.3 - protein related --> 2.3.4 - chaperoning, repair (refolding)
  5 - cell processes --> 5.1 - cell division
  8 - extrachromosomal --> 8.1 - prophage genes and phage related functions
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0032991 - protein-containing complex
molecular_function GO:0019904 - protein domain specific binding
GO:0005515 - protein binding
GO:0051082 - unfolded protein binding
GO:0000774 - adenyl-nucleotide exchange factor activity
GO:0042803 - protein homodimerization activity
GO:0051087 - chaperone binding
biological_process GO:0006457 - protein folding
GO:0009408 - response to heat
GO:0050790 - regulation of catalytic activity
GO:0065003 - protein-containing complex assembly
GO:0051085 - chaperone cofactor-dependent protein refolding
GO:0043335 - protein unfolding
External database links:  
DIP:
DIP-6141N
DISPROT:
DP00103
ECOCYC:
EG10416-MONOMER
ECOLIWIKI:
b2614
INTERPRO:
IPR009012
INTERPRO:
IPR013805
INTERPRO:
IPR000740
MINT:
MINT-1225400
MODBASE:
P09372
PANTHER:
PTHR21237
PDB:
1DKG
PFAM:
PF01025
PRIDE:
P09372
PRINTS:
PR00773
PRODB:
PRO_000022840
PROSITE:
PS01071
REFSEQ:
NP_417104
SMR:
P09372
UNIPROT:
P09372


Operon      
Name: grpE         
Operon arrangement:
Transcription unit        Promoter
grpE


Transcriptional Regulation      
Display Regulation             
Activated by: CRP


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2962 2749213 forward nd [RS-EPT-CBR] [1]
  promoter nadKp2 2750763 forward Similarity to the consensus
Read more >
[ICWHO] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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