RegulonDB RegulonDB 10.8: Gene Form
   

hypB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

hypD hypB hypA hypC hypE FNR FNR ModE hypBp hypBp

Gene      
Name: hypB    Texpresso search in the literature
Synonym(s): ECK2722, EG10484, b2727, hydB
Genome position(nucleotides): 2851001 --> 2851873 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
55.21
External database links:  
ASAP:
ABE-0008960
CGSC:
33110
ECHOBASE:
EB0479
OU-MICROARRAY:
b2727
PortEco:
hypB
STRING:
511145.b2727
COLOMBOS: hypB


Shine dalgarno      
Sequence: gaaatagaccAGGAGTgagcgATG


Product      
Name: hydrogenase isoenzymes nickel incorporation protein HypB
Synonym(s): HydB, HypB, accessory protein for nickel incorporation into hydrogenase isoenzymes
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 31.565
Isoelectric point: 5.397
Motif(s):
 
Type Positions Sequence
117 -> 117 K
2 -> 2 C
7 -> 7 C
224 -> 224 K
166 -> 166 C

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.5 - fermentation
  2 - information transfer --> 2.3 - protein related --> 2.3.4 - chaperoning, repair (refolding)
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0005515 - protein binding
GO:0016787 - hydrolase activity
GO:0046872 - metal ion binding
GO:0000166 - nucleotide binding
GO:0003924 - GTPase activity
GO:0016151 - nickel cation binding
GO:0005525 - GTP binding
GO:0008270 - zinc ion binding
GO:0042803 - protein homodimerization activity
biological_process GO:0051188 - cofactor biosynthetic process
GO:0051604 - protein maturation
Note(s): Note(s): ...[more].
Reference(s): [1] Khorasani-Motlagh M., et al., 2017
External database links:  
DIP:
DIP-36428N
ECOCYC:
EG10484-MONOMER
ECOLIWIKI:
b2727
INTERPRO:
IPR003495
INTERPRO:
IPR004392
INTERPRO:
IPR012202
INTERPRO:
IPR027417
MINT:
P0AAN3
MODBASE:
P0AAN3
PANTHER:
PTHR30134:SF2
PFAM:
PF02492
PRIDE:
P0AAN3
PRODB:
PRO_000022973
REFSEQ:
NP_417207
SMR:
P0AAN3
UNIPROT:
P0AAN3


Operon      
Name: hypABCDE-fhlA         
Operon arrangement:
Transcription unit        Promoter
hypABCDE
hypABCDE-fhlA
hypBCDE
hypBCDE-fhlA


Transcriptional Regulation      
Display Regulation             
Activated by: FhlA, FNR, IHF
Repressed by: NsrR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Khorasani-Motlagh M., Lacasse MJ., Zamble DB., 2017, High-affinity metal binding by the Escherichia coli [NiFe]-hydrogenase accessory protein HypB is selectively modulated by SlyD., Metallomics 9(5):482-493


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