RegulonDB RegulonDB 10.9: Gene Form
   

malX gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

malX malY malI MalI CRP MalI CRP anti-terminator anti-anti-terminator malYp malYp malXp malXp TSS_1899 TSS_1899 malIp malIp

Gene      
Name: malX    Texpresso search in the literature
Synonym(s): ECK1616, EG10563, b1621
Genome position(nucleotides): 1699355 --> 1700947 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
52.73
External database links:  
ASAP:
ABE-0005429
CGSC:
32254
ECHOBASE:
EB0558
ECOLIHUB:
malX
OU-MICROARRAY:
b1621
STRING:
511145.b1621
COLOMBOS: malX


Shine dalgarno      
Sequence: gttctctacgAGGAGTcgttttATG


Product      
Name: PTS enzyme IIBC component MalX
Synonym(s): EIIBCmalX, Enzyme IIBCmalX, MalX
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 56.627
Isoelectric point: 8.668
Motif(s):
 
Type Positions Sequence
138 -> 158 ILGIQSIDTGILGAVIAGIIV
189 -> 209 LVMGLVGLVIPLVWPIFAMGI
289 -> 309 FLSQGKMPAFLGGLPGAALAM
296 -> 296 P
321 -> 341 IKGLLISGLIACVVGGTTEPL

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.4 - Group Translocators --> 4.4.A - Phosphotransferase Systems (PEP-dependent PTS)
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005515 - protein binding
GO:0016740 - transferase activity
GO:0016301 - kinase activity
GO:0008982 - protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO:0005363 - maltose transmembrane transporter activity
GO:0055056 - D-glucose transmembrane transporter activity
GO:0090563 - protein-phosphocysteine-sugar phosphotransferase activity
GO:0090564 - protein-phosphocysteine-glucose phosphotransferase system transporter activity
biological_process GO:0008643 - carbohydrate transport
GO:0009401 - phosphoenolpyruvate-dependent sugar phosphotransferase system
GO:0016310 - phosphorylation
GO:0015768 - maltose transport
GO:0046323 - glucose import
GO:0009758 - carbohydrate utilization
GO:1904659 - glucose transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Postma PW., et al., 1993
External database links:  
DIP:
DIP-10150N
ECOCYC:
MALX-MONOMER
ECOLIWIKI:
b1621
INTERPRO:
IPR036878
INTERPRO:
IPR011301
INTERPRO:
IPR018113
INTERPRO:
IPR004719
INTERPRO:
IPR013013
INTERPRO:
IPR001996
INTERPRO:
IPR003352
MODBASE:
P19642
PFAM:
PF00367
PFAM:
PF02378
PRIDE:
P19642
PRODB:
PRO_000023156
PROSITE:
PS51103
PROSITE:
PS51098
PROSITE:
PS01035
REFSEQ:
NP_416138
SMR:
P19642
UNIPROT:
P19642


Operon      
Name: malXY         
Operon arrangement:
Transcription unit        Promoter
malXY
malY


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: MalI


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1899 1699241 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Postma PW., Lengeler JW., Jacobson GR., 1993, Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria., Microbiol Rev 57(3):543-94

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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