RegulonDB

Gene
Name:	mrp
Synonym(s):	ECK2106, EG10611, b2113
Genome position(nucleotides):	2193059 <-- 2194168 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	53.96
External database links:

ASAP:	ABE-0006987
ECHOBASE:	EB0606
ECOLIHUB:	mrp
MIM:	252010
OU-MICROARRAY:	b2113
STRING:	511145.b2113
COLOMBOS:	mrp

Product

Name:

P-loop NTPase family protein Mrp

Synonym(s):

Mrp

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

39.938

Isoelectric point:

6.275

Motif(s):

Type	Positions	Sequence
	106 -> 349	VKNIIAVSSGKGGVGKSSTAVNLALALAAEGAKVGILDADIYGPSIPTMLGAENQRPTSPDGTHMAPIMSHGLATNSIGYLVTDDNAMVWRGPMASKALMQMLQETLWPDLDYLVLDMPPGTGDIQLTLAQNIPVTGAVVVTTPQDIALIDAKKGIVMFEKVEVPVLGIVENMSVHICSNCGHHEPIFGTGGAEKLAEKYHTQLLGQMPLHISLREDLDKGTPTVISRPESEFTAIYRQLADRV
	115 -> 122	GKGGVGKS

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0016787 - hydrolase activity GO:0016887 - ATP hydrolysis activity GO:0046872 - metal ion binding GO:0000166 - nucleotide binding GO:0005524 - ATP binding GO:0051536 - iron-sulfur cluster binding GO:0051539 - 4 iron, 4 sulfur cluster binding
	biological_process	GO:0016226 - iron-sulfur cluster assembly

Note(s):

Note(s): ...[more].

Reference(s):

[1] Dardel F., et al., 1991
[2] Gerard E., et al., 1998
[3] High NJ., et al., 1996

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PFAM:

PRIDE:

PRODB:

PROSITE:

REFSEQ:

UNIPROT:

Operon

Name:

mrp

Operon arrangement:

Transcription unit	Promoter
mrp	mrpp

RNA cis-regulatory element

Attenuation:	Translational

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_2437	2192686	forward	nd	[RS-EPT-CBR]	[4]
promoter	yehEp7	2192880	reverse	nd	[ICWHO]	[5]
promoter	yehEp8	2192901	reverse	nd	[ICWHO]	[5]
promoter	yehEp1	2192909	reverse	nd	[ICWHO]	[5]
promoter	mrpp2	2194175	reverse	nd	[ICWHO]	[5]
promoter	mrpp7	2194180	reverse	nd	[ICWHO]	[5]
promoter	TSS_2438	2194185	reverse	nd	[RS-EPT-CBR]	[4]
promoter	TSS_2439 (cluster)	2194194	reverse	nd	[RS-EPT-CBR]	[4]
promoter	TSS_2440 (cluster)	2194200	reverse	nd	[RS-EPT-CBR]	[4]
promoter	TSS_2441	2194222	reverse	nd	[RS-EPT-CBR]	[4]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Dardel F., Panvert M., Blanquet S., Fayat G., 1991, Locations of the metG and mrp genes on the physical map of Escherichia coli., J Bacteriol 173(11):3273
[2] Gerard E., Labedan B., Forterre P., 1998, Isolation of a minD-like gene in the hyperthermophilic archaeon Pyrococcus AL585, and phylogenetic characterization of related proteins in the three domains of life., Gene 222(1):99-106
[3] High NJ., Deadman ME., Hood DW., Moxon ER., 1996, The identification a novel gene required for lipopolysaccharide biosynthesis by Haemophilus influenzae RM7004, using transposon Tn916 mutagenesis., FEMS Microbiol Lett 145(3):325-31
[4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[5] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78