RegulonDB RegulonDB 10.9: Gene Form
   

trpE gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

trpD trpE trpC trpL Cis-reg; leader anti-anti-terminator anti-terminator terminator TSS_1700 TSS_1700 TSS_1699 TSS_1699 TSS_1698 TSS_1698 TSS_1697 TSS_1697 TSS_1696 TSS_1696 TSS_1695 TSS_1695 trpCp trpCp TSS_1694 TSS_1694 TSS_1693 TSS_1693 TSS_1692 TSS_1692 TSS_1691 TSS_1691 TSS_1690 (cluster) TSS_1690 (cluster) TSS_1689 TSS_1689

Gene      
Name: trpE    Texpresso search in the literature
Synonym(s): ECK1258, EG11028, anth, b1264, tryD, tryp-4
Genome position(nucleotides): 1321384 <-- 1322946 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
54.38
External database links:  
ASAP:
ABE-0004244
CGSC:
70
ECHOBASE:
EB1021
ECOLIHUB:
trpE
OU-MICROARRAY:
b1264
STRING:
511145.b1264
COLOMBOS: trpE


Product      
Name: anthranilate synthase subunit TrpE
Synonym(s): alpha; subunit, TrpE, TryD, anthranilate synthase component I
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 57.495
Isoelectric point: 5.181
Motif(s):
 
Type Positions Sequence
147 -> 147 G
19 -> 191 DNPTALFHQLCGDRPATLLLESADIDSKDDLKSLLLVDSALRITALGDTVTIQALSGNGEALLALLDNALPAGVESEQSPNCRVLRFPPVSPLLDEDARLCSLSVFDAFRLLQNLLNVPKEEREAMFFGGLFSYDLVAGFEDLPQLSAENNCPDFCFYLAETLMVIDHQKKST
483 -> 485 GAG
328 -> 329 GT
13 -> 13 C

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.15 - tryptophan
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016829 - lyase activity
GO:0046872 - metal ion binding
GO:0004049 - anthranilate synthase activity
biological_process GO:0008152 - metabolic process
GO:0000162 - tryptophan biosynthetic process
GO:0008652 - cellular amino acid biosynthetic process
GO:0009058 - biosynthetic process
GO:0009073 - aromatic amino acid family biosynthetic process
External database links:  
ECOCYC:
ANTHRANSYNCOMPI-MONOMER
ECOLIWIKI:
b1264
INTERPRO:
IPR005257
INTERPRO:
IPR019999
INTERPRO:
IPR015890
INTERPRO:
IPR006805
INTERPRO:
IPR005801
MODBASE:
P00895
PANTHER:
PTHR11236:SF22
PFAM:
PF00425
PFAM:
PF04715
PRIDE:
P00895
PRINTS:
PR00095
PRODB:
PRO_000024121
REFSEQ:
NP_415780
SMR:
P00895
SWISSMODEL:
P00895
UNIPROT:
P00895


Operon      
Name: trpLEDCBA         
Operon arrangement:
Transcription unit        Promoter
trpCBA
trpL
trpLEDCBA


Transcriptional Regulation      
Display Regulation             
Repressed by: TrpR


RNA cis-regulatory element    
Attenuation: Transcriptional


Regulation by small RNA    
  Display Regulation
small RNA rydC


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1689 1318430 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1690 (cluster) 1318512 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_1691 1318516 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1692 1318535 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1693 1318537 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1694 1318607 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1695 1321481 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1696 1321882 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1697 1321905 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1698 1322038 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1699 1322047 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1700 1322139 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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