RegulonDB RegulonDB 11.1: Gene Form
   

uvrB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

uvrB ybhK bioD ybhU bioC DnaA LexA DnaA DnaA DnaA LexA LexA DnaA DnaA LexA DnaA uvrBp1 uvrBp1 uvrBp2 uvrBp2 uvrBp3 uvrBp3

Gene      
Name: uvrB    Texpresso search in the literature
Synonym(s): ECK0768, EG11062, b0779, dar-1, dar-6
Genome position(nucleotides): 813526 --> 815547
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.56
External database links:  
ASAP:
 ABE-0002658
CGSC:
 20
ECHOBASE:
 EB1055
ECOLIHUB:
 uvrB
OU-MICROARRAY:
 b0779
STRING:
 511145.b0779
COLOMBOS: uvrB


Shine dalgarno      
Sequence: caactccttcAGGTAGcgactcATG


Product      
Name: UvrABC excision nuclease subunit B
Synonym(s): UvrB, excision nuclease subunit B
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 76.226
Isoelectric point: 4.889
Motif(s):
 
Type Positions Sequence Comment
2 -> 673 SKPFKLNSAFKPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKAMLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTVGMIIDQRAILRRLAELQYARNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQIVSTIPRFTIYPKTHYVTPRERIVQAMEEIKEELAARRKVLLENNKLLEEQRLTQRTQFDLEMMNELGYCSGIENYSRFLSGRGPGEPPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYELEKSGGDVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRQRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDIDTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDKITPSMAKAIGETERRREKQQKYNEEHGITPQGLNKKVVDILALGQNIAKTKAKGRGKSRPIVEPDNVPMDMSPKALQQKIHELEGLMMQHAQNLEFEEAAQIRDQLHQLRELFIAAS UniProt: UvrABC system protein B.
13 -> 92 PSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEFFPENAVEYFVSY
26 -> 415 EGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKAMLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTVGMIIDQRAILRRLAELQYARNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQIVSTIPRFTIYPKTHYVTPRERIVQAMEEIKEELAARRKVLLENNKLLEEQRLTQRTQFDLEMMNELGYCSGIENYSRFLSGRGPGEPPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYELEKSGGDVVDQVVRP UniProt: Helicase ATP-binding.
39 -> 46 GVTGSGKT UniProt: ATP.
92 -> 115 YYDYYQPEAYVPSSDTFIEKDASV UniProt: Beta-hairpin; Sequence Annotation Type: short sequence motif.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.2 - DNA
  2 - information transfer --> 2.1 - DNA related --> 2.1.4 - DNA repair
  2 - information transfer --> 2.1 - DNA related --> 2.1.5 - DNA degradation
  5 - cell processes --> 5.6 - protection --> 5.6.1 - radiation
  5 - cell processes --> 5.8 - SOS response
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0009380 - excinuclease repair complex
molecular_function GO:0003677 - DNA binding
GO:0004518 - nuclease activity
GO:0005515 - protein binding
GO:0016787 - hydrolase activity
GO:0016887 - ATP hydrolysis activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0009381 - excinuclease ABC activity
GO:0042802 - identical protein binding
biological_process GO:0006294 - nucleotide-excision repair, preincision complex assembly
GO:0006281 - DNA repair
GO:0006974 - cellular response to DNA damage stimulus
GO:0009432 - SOS response
GO:0009314 - response to radiation
GO:0006289 - nucleotide-excision repair
GO:0000715 - nucleotide-excision repair, DNA damage recognition
GO:0033683 - nucleotide-excision repair, DNA incision
Note(s): Note(s): ...[more].
Reference(s): [1] Byrne RT., et al., 2014
External database links:  
ALPHAFOLD:
 P0A8F8
DIP:
 DIP-48012N
ECOCYC:
 EG11062-MONOMER
ECOLIWIKI:
 b0779
INTERPRO:
 IPR001943
INTERPRO:
 IPR001650
INTERPRO:
 IPR041471
INTERPRO:
 IPR004807
INTERPRO:
 IPR006935
INTERPRO:
 IPR014001
INTERPRO:
 IPR024759
INTERPRO:
 IPR027417
INTERPRO:
 IPR036876
PANTHER:
 PTHR24029
PDB:
 1QOJ
PDB:
 1E52
PFAM:
 PF17757
PFAM:
 PF12344
PFAM:
 PF04851
PFAM:
 PF02151
PFAM:
 PF00271
PRIDE:
 P0A8F8
PRODB:
 PRO_000024199
PROSITE:
 PS50151
PROSITE:
 PS51192
PROSITE:
 PS51194
REFSEQ:
 NP_415300
SMART:
 SM00487
SMART:
 SM00490
SMR:
 P0A8F8
UNIPROT:
 P0A8F8


Operon      
Name: uvrB         
Operon arrangement:
Transcription unit        Promoter
uvrB
uvrB
uvrB


Transcriptional Regulation      
Display Regulation             
Repressed by: DnaA, LexA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Byrne RT., Chen SH., Wood EA., Cabot EL., Cox MM., 2014, Escherichia coli genes and pathways involved in surviving extreme exposure to ionizing radiation., J Bacteriol 196(20):3534-45

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