RegulonDB

Gene
Name:	rluC
Synonym(s):	ECK1071, EG11118, b1086, yceC
Genome position(nucleotides):	1144940 --> 1145899
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	51.46
External database links:

ASAP:	ABE-0003675
ECHOBASE:	EB1108
ECOLIHUB:	rluC
OU-MICROARRAY:	b1086
STRING:	511145.b1086
COLOMBOS:	rluC

Product

Name:

23S rRNA pseudouridine^{955/2504/2580} synthase

Synonym(s):

RluC, YceC, ribosomal large subunit (23S rRNA) pseudouridine synthase C, ribosomal large subunit pseudouridine synthase C

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

36.027

Isoelectric point:

10.452

Motif(s):

Type	Positions	Sequence	Comment
	20 -> 66	QRIDNFLRTQLKGVPKSMIYRILRKGEVRVNKKRIKPEYKLEAGDEV
	101 -> 249	HILVLNKPSGTAVHGGSGLSFGVIEGLRALRPEARFLELVHRLDRDTSGVLLVAKKRSALRSLHEQLREKGMQKDYLALVRGQWQSHVKSVQAPLLKNILQSGERIVRVSQEGKPSETRFKVEERYAFATLVRCSPVTGRTHQIRVHTQ
	144 -> 144	D	UniProt: Does not restore cold-sensitive growth to a double bipA-rluC deletion..

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		2 - information transfer --> 2.2 - RNA related --> 2.2.3 - RNA modification
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0120159 - rRNA pseudouridine synthase activity GO:0016853 - isomerase activity GO:0003723 - RNA binding GO:0009982 - pseudouridine synthase activity
	biological_process	GO:0009451 - RNA modification GO:0001522 - pseudouridine synthesis GO:0006364 - rRNA processing GO:0000455 - enzyme-directed rRNA pseudouridine synthesis

Note(s):

Note(s): ...[more].

Reference(s):

[1] Gustafsson C., et al., 1996

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PDB:

PDB:

PFAM:

PFAM:

PRIDE:

PRODB:

PROSITE:

PROSITE:

REFSEQ:

SMART:

SMR:

UNIPROT:

Operon

Name:

rluC

Operon arrangement:

Transcription unit	Promoter
rluC

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	TSS_1364 (cluster)	1144680		reverse	nd	[RS-EPT-CBR]	[2]
	promoter	TSS_1365	1146590		forward	nd	[RS-EPT-CBR]	[2]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Gustafsson C., Reid R., Greene PJ., Santi DV., 1996, Identification of new RNA modifying enzymes by iterative genome search using known modifying enzymes as probes., Nucleic Acids Res 24(19):3756-62
[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

Reference(s)

[1] Gustafsson C., Reid R., Greene PJ., Santi DV., 1996, Identification of new RNA modifying enzymes by iterative genome search using known modifying enzymes as probes., Nucleic Acids Res 24(19):3756-62

[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.