RegulonDB

RegulonDB RegulonDB 10.8: Gene Form

uvrY gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	uvrY
Synonym(s):	ECK1913, EG11140, b1914, yecB
Genome position(nucleotides):	1994703 <-- 1995359 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	49.77
External database links:

ASAP:	ABE-0006373
ECHOBASE:	EB1130
OU-MICROARRAY:	b1914
PortEco:	uvrY
STRING:	511145.b1914
COLOMBOS:	uvrY

Product

Name:

DNA-binding transcriptional activator UvrY

Synonym(s):

UvrY, UvrY response regulator, YecB

Sequence:

Get amino acid sequence Fasta Format

Regulator Family:

LuxR/UhpA

Cellular location:

cytosol

Molecular weight:

23.893

Isoelectric point:

7.044

Motif(s):

Type	Positions	Sequence
	149 -> 204	SLSERELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLA
	8 -> 9	DD
	3 -> 119	NVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRTNAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVY
	4 -> 115	VLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRTNAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAI
	167 -> 186	VNEISEQLNLSPKTVNSYRY

Classification:

Multifun Terms (GenProtEC)
		2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.2 - activator
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol
	molecular_function	GO:0003677 - DNA binding GO:0000156 - phosphorelay response regulator activity
	biological_process	GO:0006355 - regulation of transcription, DNA-templated GO:0000160 - phosphorelay signal transduction system

Note(s):

Note(s): ...[more].

Evidence:

[AIFS] Automated inference of function from sequence
[GEA] Gene expression analysis
[IEP] Inferred from expression pattern
[IFC] Inferred by functional complementation

Reference(s):

[1] Pernestig AK., et al., 2003
[2] Pernestig AK., et al., 2001
[3] Suzuki K., et al., 2002

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MINT:

MODBASE:

PFAM:

PFAM:

PRIDE:

PRINTS:

PRODB:

PROSITE:

PROSITE:

PROSITE:

REFSEQ:

SMART:

SMART:

SMR:

UNIPROT:

Operon

Name:

uvrYC

Operon arrangement:

Transcription unit	Promoter
uvrC	uvrCp3
uvrYC	uvrYp2

Transcriptional Regulation
	Display Regulation
Repressed by:	LexA

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_2247	1992850	reverse	nd	[RS-EPT-CBR]	[4]
promoter	TSS_2248	1994876	reverse	nd	[RS-EPT-CBR]	[4]
promoter	TSS_2249 (cluster)	1995403	reverse	For this promoter, there is a cluster of 2 transcription start sites,in the interval 1995402 to 1995403, where the highest frequency is at position 1993427. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[4]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Pernestig AK., Georgellis D., Romeo T., Suzuki K., Tomenius H., Normark S., Melefors O., 2003, The Escherichia coli BarA-UvrY two-component system is needed for efficient switching between glycolytic and gluconeogenic carbon sources., J Bacteriol 185(3):843-53
[2] Pernestig AK., Melefors O., Georgellis D., 2001, Identification of UvrY as the cognate response regulator for the BarA sensor kinase in Escherichia coli., J Biol Chem 276(1):225-31
[3] Suzuki K., Wang X., Weilbacher T., Pernestig AK., Melefors O., Georgellis D., Babitzke P., Romeo T., 2002, Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli., J Bacteriol 184(18):5130-40
[4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

RegulonDB