RegulonDB

Gene
Name:	creB
Synonym(s):	ECK4390, EG11218, ORF2, b4398, yjjE
Genome position(nucleotides):	4636007 --> 4636696 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	55.22
External database links:

ASAP:	ABE-0014428
CGSC:	34803
ECHOBASE:	EB1201
ECOLIHUB:	creB
OU-MICROARRAY:	b4398
STRING:	511145.b4398
COLOMBOS:	creB

Shine dalgarno
Sequence:	ggcaataacaGAGGCGatttATG

Product

Name:

DNA-binding transcriptional regulator CreB

Synonym(s):

CreB, CreB response regulator, YjjE

Sequence:

Get amino acid sequence Fasta Format

Regulator Family:

OmpR

Cellular location:

cytosol

Molecular weight:

26.125

Isoelectric point:

6.532

Motif(s):

Type	Positions	Sequence
	5 -> 119	TVWLVEDEQGIADTLVYMLQQEGFAVEVFERGLPVLDKARKQVPDVMILDVGLPDISGFELCRQLLALHPALPVLFLTARSEEVDRLLGLEIGADDYVAKPFSPREVCARVRTLL
	129 -> 228	SPVIRIGHFELNEPAAQISWFDTPLALTRYEFLLLKTLLKSPGRVWSRQQLMDSVWEDAQDTYDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSLRG
	151 -> 226	TPLALTRYEFLLLKTLLKSPGRVWSRQQLMDSVWEDAQDTYDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSL
	6 -> 115	VWLVEDEQGIADTLVYMLQQEGFAVEVFERGLPVLDKARKQVPDVMILDVGLPDISGFELCRQLLALHPALPVLFLTARSEEVDRLLGLEIGADDYVAKPFSPREVCARV

Classification:

Multifun Terms (GenProtEC)
		2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.2 - activator
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.4 - complex regulation --> 3.1.2.4.3 - two component regulatory systems (external signal)
		3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032993 - protein-DNA complex
	molecular_function	GO:0003677 - DNA binding GO:0000156 - phosphorelay response regulator activity GO:0042802 - identical protein binding GO:0000976 - transcription cis-regulatory region binding GO:0000986 - bacterial-type cis-regulatory region sequence-specific DNA binding GO:0001216 - DNA-binding transcription activator activity
	biological_process	GO:0006355 - regulation of transcription, DNA-templated GO:0045893 - positive regulation of transcription, DNA-templated GO:0000160 - phosphorelay signal transduction system

Reference(s):

[1] Pao GM., et al., 1995
[2] Parkinson JS. 1993
[3] Parkinson JS., et al., 1992
[4] Saier MH. 1994
[5] Stock JB., et al., 1990

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PANTHER:

PFAM:

PFAM:

PRIDE:

PRODB:

PROSITE:

PROSITE:

REFSEQ:

SMART:

SMART:

SMR:

SWISSMODEL:

UNIPROT:

Operon

Name:

creABCD

Operon arrangement:

Transcription unit	Promoter
creABC	creAp2
creABCD	creAp
creD	creDp

Transcriptional Regulation
	Display Regulation
Repressed by:	NagC

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References

Reference(s)
[1] Pao GM., Saier MH., 1995, Response regulators of bacterial signal transduction systems: selective domain shuffling during evolution., J Mol Evol 40(2):136-54
[2] Parkinson JS., 1993, Signal transduction schemes of bacteria., Cell 73(5):857-71
[3] Parkinson JS., Kofoid EC., 1992, Communication modules in bacterial signaling proteins., Annu Rev Genet 26:71-112
[4] Saier MH., 1994, Bacterial sensor kinase/response regulator systems: an introduction., Res Microbiol 145(5-6):349-55
[5] Stock JB., Stock AM., Mottonen JM., 1990, Signal transduction in bacteria., Nature 344(6265):395-400