RegulonDB

Gene
Name:	hdeD
Synonym(s):	ECK3495, EG11495, b3511, yhiA
Genome position(nucleotides):	3656995 --> 3657567 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	46.6
External database links:

ASAP:	ABE-0011467
CGSC:	33737
ECHOBASE:	EB1458
ECOLIHUB:	hdeD
OU-MICROARRAY:	b3511
STRING:	511145.b3511
COLOMBOS:	hdeD

Product

Name:

acid-resistance membrane protein

Synonym(s):

HdeD, YhiA

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

20.903

Isoelectric point:

9.882

Motif(s):

Type	Positions	Sequence
	77 -> 99	WPVLSGFLVAVAYLLIGYFFIRA
	84 -> 153	LVAVAYLLIGYFFIRAPELGIFAIAAFIAGLFCVAGVIRLMSWYRQRSMKGSWLQLVIGVLDIVIAWIFL
	139 -> 161	LVIGVLDIVIAWIFLGATPMVSV
	27 -> 97	IAVLLFIVGLLCISFPFVSGDILSTVVGALLICSGIALIVGLFSNRSHNFWPVLSGFLVAVAYLLIGYFFI
	26 -> 44	FIAVLLFIVGLLCISFPFV

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		5 - cell processes --> 5.5 - adaptations --> 5.5.4 - pH
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0016021 - integral component of membrane
	biological_process	GO:0009268 - response to pH

Note(s):

Note(s): ...[more].

Evidence:

[IGI] Inferred from genetic interaction

Reference(s):

[1] Masuda N., et al., 2003

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

PFAM:

PRIDE:

PRODB:

REFSEQ:

UNIPROT:

Operon

Name:

hdeD

Operon arrangement:

Transcription unit	Promoter
hdeD	hdeDp
hdeD	hdeDp2

Transcriptional Regulation
	Display Regulation
Activated by:	PhoP, GadX, RcsB, GadE
Repressed by:	H-NS

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_4118	3656618	reverse	nd	[RS-EPT-CBR]	[2]
promoter	TSS_4119	3656719	reverse	nd	[RS-EPT-CBR]	[2]
promoter	TSS_4120	3656761	reverse	nd	[RS-EPT-CBR]	[2]
promoter	TSS_4123 (cluster)	3656977	forward	nd	[RS-EPT-CBR]	[2]
promoter	TSS_4124 (cluster)	3657010	forward	nd	[RS-EPT-CBR]	[2]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Masuda N., Church GM., 2003, Regulatory network of acid resistance genes in Escherichia coli., Mol Microbiol 48(3):699-712
[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

Reference(s)

[1] Masuda N., Church GM., 2003, Regulatory network of acid resistance genes in Escherichia coli., Mol Microbiol 48(3):699-712

[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.