RegulonDB RegulonDB 10.10: Gene Form
   

ftsH gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ftsH folP rlmE glmM anti-anti-terminator anti-terminator terminator TSS_3487 TSS_3487 TSS_3486 (cluster) TSS_3486 (cluster) ftsHp1 ftsHp1 ftsHp4 ftsHp4 TSS_3484 TSS_3484 TSS_3483 TSS_3483 TSS_3482 TSS_3482 TSS_3481 TSS_3481 TSS_3480 TSS_3480 TSS_3479 TSS_3479 TSS_3478 TSS_3478 TSS_3477 TSS_3477

Gene      
Name: ftsH    Texpresso search in the literature
Synonym(s): ECK3167, EG11506, b3178, hflB, mrsC, std, tolZ
Genome position(nucleotides): 3325001 <-- 3326935 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.59
External database links:  
ASAP:
 ABE-0010444
CGSC:
 735
ECHOBASE:
 EB1469
ECOLIHUB:
 ftsH
MIM:
 610246
MIM:
 614487
OU-MICROARRAY:
 b3178
STRING:
 511145.b3178
COLOMBOS: ftsH


Product      
Name: ATP-dependent zinc metalloprotease FtsH
Synonym(s): FtsH, HflB, MrsC, Std, TolZ
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 70.708
Isoelectric point: 6.122
Motif(s):
 
Type Positions Sequence
418 -> 418 H
463 -> 463 E
476 -> 476 E
192 -> 199 GPPGTGKT
226 -> 226 V

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.3 - proteins/peptides/glycopeptides
  2 - information transfer --> 2.3 - protein related --> 2.3.6 - turnover, degradation
  5 - cell processes --> 5.1 - cell division
  6 - cell structure --> 6.1 - membrane
  8 - extrachromosomal --> 8.2 - plasmid related
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0098796 - membrane protein complex
molecular_function GO:0005515 - protein binding
GO:0008233 - peptidase activity
GO:0016787 - hydrolase activity
GO:0016887 - ATP hydrolysis activity
GO:0046872 - metal ion binding
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0004176 - ATP-dependent peptidase activity
GO:0008270 - zinc ion binding
GO:0004222 - metalloendopeptidase activity
GO:0008237 - metallopeptidase activity
biological_process GO:0006508 - proteolysis
GO:0030163 - protein catabolic process
Note(s): Note(s): ...[more].
Reference(s): [1] Begg KJ., et al., 1992
[2] Makino S., et al., 1997
[3] Teff D., et al., 2000
External database links:  
DIP:
 DIP-35828N
ECOCYC:
 EG11506-MONOMER
ECOLIWIKI:
 b3178
INTERPRO:
 IPR003593
INTERPRO:
 IPR041569
INTERPRO:
 IPR000642
INTERPRO:
 IPR037219
INTERPRO:
 IPR003959
INTERPRO:
 IPR003960
INTERPRO:
 IPR005936
INTERPRO:
 IPR011546
INTERPRO:
 IPR027417
MINT:
 P0AAI3
MODBASE:
 P0AAI3
PDB:
 4V0B
PDB:
 1LV7
PFAM:
 PF00004
PFAM:
 PF01434
PFAM:
 PF06480
PFAM:
 PF17862
PRIDE:
 P0AAI3
PRODB:
 PRO_000022717
PROSITE:
 PS00674
REFSEQ:
 NP_417645
SMART:
 SM00382
SMR:
 P0AAI3
SWISSMODEL:
 P0AAI3
UNIPROT:
 P0AAI3


Operon      
Name: rlmE-ftsH         
Operon arrangement:
Transcription unit        Promoter
rlmE-ftsH
rlmE-ftsH


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3477 3324129 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3478 3324319 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3479 3324325 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3480 3325230 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3481 3325234 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3482 3325504 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3483 3325595 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3484 3326682 reverse nd [RS-EPT-CBR] [4]
  promoter ftsHp4 3326978 reverse nd [ICWHO], [RS-EPT-CBR] [4], [5]
  promoter ftsHp1 3327102 reverse nd [ICWHO] [5]
  promoter TSS_3486 (cluster) 3327294 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3487 3327347 reverse nd [RS-EPT-CBR] [4]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Begg KJ., Tomoyasu T., Donachie WD., Khattar M., Niki H., Yamanaka K., Hiraga S., Ogura T., 1992, Escherichia coli mutant Y16 is a double mutant carrying thermosensitive ftsH and ftsI mutations., J Bacteriol 174(7):2416-7

 [2] Makino S., Qu JN., Uemori K., Ichikawa H., Ogura T., Matsuzawa H., 1997, A silent mutation in the ftsH gene of Escherichia coli that affects FtsH protein production and colicin tolerance., Mol Gen Genet 254(5):578-83

 [3] Teff D., Koby S., Shotland Y., Ogura T., Oppenheim AB., 2000, A colicin-tolerant Escherichia coli mutant that confers hfl phenotype carries two mutations in the region coding for the C-terminal domain of FtsH (HflB)., FEMS Microbiol Lett 183(1):115-7

 [4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [5] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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