Gene
Name:	ftsH
Synonym(s):	ECK3167, EG11506, b3178, hflB, mrsC, std, tolZ
Genome position(nucleotides):	3325001 <-- 3326935 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	53.59
External database links:

ASAP:	ABE-0010444
CGSC:	735
ECHOBASE:	EB1469
ECOLIHUB:	ftsH
MIM:	610246
MIM:	614487
OU-MICROARRAY:	b3178
STRING:	511145.b3178
COLOMBOS:	ftsH

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_3477	3324129	reverse	nd	[RS-EPT-CBR]	[4]
promoter	TSS_3478	3324319	reverse	nd	[RS-EPT-CBR]	[4]
promoter	TSS_3479	3324325	reverse	nd	[RS-EPT-CBR]	[4]
promoter	TSS_3480	3325230	reverse	nd	[RS-EPT-CBR]	[4]
promoter	TSS_3481	3325234	reverse	nd	[RS-EPT-CBR]	[4]
promoter	TSS_3482	3325504	reverse	nd	[RS-EPT-CBR]	[4]
promoter	TSS_3483	3325595	reverse	nd	[RS-EPT-CBR]	[4]
promoter	TSS_3484	3326682	reverse	nd	[RS-EPT-CBR]	[4]
promoter	ftsHp4	3326978	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 5.063. P-value: 2.306e-6 Read more >	[ICWHO], [RS-EPT-CBR]	[4], [5]
promoter	ftsHp1	3327102	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: poor homology. Score: 1.59. P-value: 3.152e-7 Read more >	[ICWHO]	[5]
promoter	TSS_3486 (cluster)	3327294	reverse	For this promoter, there is a cluster of 2 transcription start sites,in the interval 3327293 to 3327294, where the highest frequency is at position 3325315. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[4]
promoter	TSS_3487	3327347	reverse	nd	[RS-EPT-CBR]	[4]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Begg KJ., Tomoyasu T., Donachie WD., Khattar M., Niki H., Yamanaka K., Hiraga S., Ogura T., 1992, Escherichia coli mutant Y16 is a double mutant carrying thermosensitive ftsH and ftsI mutations., J Bacteriol 174(7):2416-7
[2] Makino S., Qu JN., Uemori K., Ichikawa H., Ogura T., Matsuzawa H., 1997, A silent mutation in the ftsH gene of Escherichia coli that affects FtsH protein production and colicin tolerance., Mol Gen Genet 254(5):578-83
[3] Teff D., Koby S., Shotland Y., Ogura T., Oppenheim AB., 2000, A colicin-tolerant Escherichia coli mutant that confers hfl phenotype carries two mutations in the region coding for the C-terminal domain of FtsH (HflB)., FEMS Microbiol Lett 183(1):115-7
[4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[5] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78