RegulonDB RegulonDB 11.1: Gene Form
   

caiC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

caiC caiB caiD TSS_81 TSS_81 caiEp3 caiEp3 caiEp5 caiEp5 caiEp7 caiEp7

Gene      
Name: caiC    Texpresso search in the literature
Synonym(s): ECK0038, EG11558, b0037, yaaM
Genome position(nucleotides): 36271 <-- 37824
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.03
External database links:  
ASAP:
 ABE-0000133
CGSC:
 36828
ECHOBASE:
 EB1519
ECOLIHUB:
 caiC
OU-MICROARRAY:
 b0037
STRING:
 511145.b0037
COLOMBOS: caiC


Product      
Name: carnitine—CoA ligase
Synonym(s): CaiC, YaaM
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 58.559
Isoelectric point: 5.69
Motif(s):
 
Type Positions Sequence Comment
17 -> 426 ADVYGHKTALICESSGGVVNRYSYLELNQEINRTANLFYTLGIRKGDKVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLCEESAWILQNSQACLLVTSAQFYPMYQQIQQEDATQLRHICLTDVALPADDGVSSFTQLKNQQPATLCYAPPLSTDDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQCALRDDDVYLTVMPAFHIDCQCTAAMAAFSAGATFVLVEKYSARAFWGQVQKYRATVTECIPMMIRTLMVQPPSANDQQHRLREVMFYLNLSEQEKDAFCERFGVRLLTSYGMTETIVGIIGDRPGDKRRWPSIGRVGFCYEAEIRDDHNRPLPAGEIGEICIKGIPGKTIFKEYFLNPQATAKVLEADGWLHTGDTGYRDEEDFFYFVDRRCNMIKR
98 -> 98 C UniProt: In strain: O44:K74..
252 -> 253 RA UniProt: In strain: O44:K74..
286 -> 286 Q UniProt: In strain: O44:K74 and B..
328 -> 328 I UniProt: In strain: O44:K74..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.4 - amines
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0005515 - protein binding
GO:0016874 - ligase activity
GO:0016405 - CoA-ligase activity
GO:0016878 - acid-thiol ligase activity
GO:0051108 - carnitine-CoA ligase activity
GO:0051109 - crotonobetaine-CoA ligase activity
biological_process GO:0009437 - carnitine metabolic process
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P31552
DIP:
 DIP-9243N
ECOCYC:
 CAIC-MONOMER
ECOLIWIKI:
 b0037
INTERPRO:
 IPR042099
INTERPRO:
 IPR025110
INTERPRO:
 IPR020845
INTERPRO:
 IPR000873
INTERPRO:
 IPR023456
MODBASE:
 P31552
PFAM:
 PF00501
PFAM:
 PF13193
PRIDE:
 P31552
PROSITE:
 PS00455
REFSEQ:
 NP_414579
SMR:
 P31552
UNIPROT:
 P31552


Operon      
Name: caiTABCDE         
Operon arrangement:
Transcription unit        Promoter
caiTABCDE
caiCDE


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, FNR, ArcA, CaiF
Repressed by: H-NS


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter caiEp7 35399 reverse nd [COMP-AINF] [1]
  promoter caiEp5 35440 reverse nd [COMP-AINF] [1]
  promoter caiEp3 35499 reverse nd [COMP-AINF] [1]
  promoter TSS_81 38400 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

RegulonDB