RegulonDB RegulonDB 10.10: Gene Form
   

galP gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

galP metK yggI GalS GalR NagC CRP GalS GalR GalS GalR GalS GalR GalS GalR GalS GalR terminator anti-terminator anti-anti-terminator yggIp4 yggIp4 yggIp5 yggIp5 yggIp3 yggIp3 yggIp6 yggIp6 galPp galPp TSS_3268 TSS_3268 TSS_3267 (cluster) TSS_3267 (cluster)

Gene      
Name: galP    Texpresso search in the literature
Synonym(s): ECK2938, EG12148, Pgal, b2943
Genome position(nucleotides): 3088284 --> 3089678 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.12
External database links:  
ASAP:
 ABE-0009654
CGSC:
 722
ECHOBASE:
 EB2068
ECOLIHUB:
 galP
OU-MICROARRAY:
 b2943
STRING:
 511145.b2943
COLOMBOS: galP


Product      
Name: galactose:H+ symporter
Synonym(s): GalP
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 50.982
Isoelectric point: 9.838
Motif(s):
 
Type Positions Sequence
16 -> 36 FFVCFLAALAGLLFGLDIGVI
18 -> 450 VCFLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEAKRELDEIRESLQVKQSGWALFKENSNFRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTMMHIGIHSPSAQYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNANTFWVYAALNVLFILLTLWLVPETKHVSLEHIERN
395 -> 415 WIANMIVGATFLTMLNTLGNA
417 -> 437 TFWVYAALNVLFILLTLWLVP
172 -> 192 WMLGVIIIPAILLLIGVFFLP

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015293 - symporter activity
GO:0015517 - galactose:proton symporter activity
GO:0022857 - transmembrane transporter activity
biological_process GO:0008643 - carbohydrate transport
GO:0015757 - galactose transmembrane transport
GO:0055085 - transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
 GALP-MONOMER
ECOLIWIKI:
 b2943
INTERPRO:
 IPR036259
INTERPRO:
 IPR020846
INTERPRO:
 IPR005829
INTERPRO:
 IPR003663
INTERPRO:
 IPR005828
MODBASE:
 P0AEP1
PFAM:
 PF00083
PRIDE:
 P0AEP1
PRINTS:
 PR00171
PRODB:
 PRO_000022746
PROSITE:
 PS00216
PROSITE:
 PS50850
PROSITE:
 PS00217
REFSEQ:
 NP_417418
UNIPROT:
 P0AEP1


Operon      
Name: galP         
Operon arrangement:
Transcription unit        Promoter
galP


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: NagC, GalS, GalR


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3267 (cluster) 3087216 forward nd [RS-EPT-CBR] [1]
  promoter TSS_3268 3087246 forward nd [RS-EPT-CBR] [1]
  promoter yggIp6 3089588 forward nd [ICWHO] [2]
  promoter yggIp3 3089659 forward nd [ICWHO] [2]
  promoter yggIp5 3089749 forward nd [ICWHO] [2]
  promoter yggIp4 3089752 forward nd [ICWHO] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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