RegulonDB RegulonDB 10.9: Gene Form
   

folP gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ftsH glmM folP secG anti-anti-terminator anti-terminator terminator anti-anti-terminator anti-terminator terminator TSS_3484 TSS_3484 TSS_3483 TSS_3483 TSS_3482 TSS_3482 TSS_3481 TSS_3481 TSS_3480 TSS_3480 TSS_3479 TSS_3479 TSS_3478 TSS_3478 TSS_3477 TSS_3477 TSS_3476 TSS_3476 secGp2 secGp2 secGp1 secGp1 leuUp leuUp

Gene      
Name: folP    Texpresso search in the literature
Synonym(s): ECK3166, EG50011, b3177, dhpS
Genome position(nucleotides): 3324063 <-- 3324911 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.59
Reference(s): [1] Dallas WS., et al., 1993
[2] Dallas WS., et al., 1992
[3] Peters JE., et al., 2003
External database links:  
ASAP:
ABE-0010441
CGSC:
29566
ECHOBASE:
EB4304
ECOLIHUB:
folP
OU-MICROARRAY:
b3177
STRING:
511145.b3177
COLOMBOS: folP


Product      
Name: dihydropteroate synthase
Synonym(s): DhpS, FolP
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 30.615
Isoelectric point: 5.957
Motif(s):
 
Type Positions Sequence
18 -> 257 MGILNVTPDSFSDGGTHNSLIDAVKHANLMINAGATIIDVGGESTRPGAAEVSVEEELQRVIPVVEAIAQRFEVWISVDTSKPEVIRESAKVGAHIINDIRSLSEPGALEAAAETGLPVCLMHMQGNPKTMQEAPKYDDVFAEVNRYFIEQIARCEQAGIAKEKLLLDPGFGFGKNLSHNYSLLARLAEFHHFNLPLLVGMSRKSMIGQLLNVGPSERLSGSLACAVIAAMQGAHIIRVH
77 -> 77 R
255 -> 257 RVH
28 -> 28 F
6 -> 6 Q

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.2 - folic acid
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0016740 - transferase activity
GO:0046872 - metal ion binding
GO:0004156 - dihydropteroate synthase activity
GO:0042803 - protein homodimerization activity
biological_process GO:0044237 - cellular metabolic process
GO:0009396 - folic acid-containing compound biosynthetic process
GO:0042558 - pteridine-containing compound metabolic process
GO:0042493 - response to drug
GO:0046656 - folic acid biosynthetic process
GO:0046654 - tetrahydrofolate biosynthetic process
External database links:  
DIP:
DIP-47922N
ECOCYC:
H2PTEROATESYNTH-MONOMER
ECOLIWIKI:
b3177
INTERPRO:
IPR011005
INTERPRO:
IPR006390
INTERPRO:
IPR000489
MODBASE:
P0AC13
PDB:
1AJ2
PDB:
1AJZ
PDB:
1AJ0
PFAM:
PF00809
PRIDE:
P0AC13
PRODB:
PRO_000022682
PROSITE:
PS50972
PROSITE:
PS00793
PROSITE:
PS00792
REFSEQ:
NP_417644
SMR:
P0AC13
UNIPROT:
P0AC13


Operon      
Name: folP-glmM         
Operon arrangement:
Transcription unit        Promoter
folP-glmM


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3476 3323735 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3477 3324129 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3478 3324319 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3479 3324325 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3480 3325230 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3481 3325234 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3482 3325504 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3483 3325595 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_3484 3326682 reverse nd [RS-EPT-CBR] [4]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Dallas WS., Dev IK., Ray PH., 1993, The dihydropteroate synthase gene, folP, is near the leucine tRNA gene, leuU, on the Escherichia coli chromosome., J Bacteriol 175(23):7743-4

 [2] Dallas WS., Gowen JE., Ray PH., Cox MJ., Dev IK., 1992, Cloning, sequencing, and enhanced expression of the dihydropteroate synthase gene of Escherichia coli MC4100., J Bacteriol 174(18):5961-70

 [3] Peters JE., Thate TE., Craig NL., 2003, Definition of the Escherichia coli MC4100 genome by use of a DNA array., J Bacteriol 185(6):2017-21

 [4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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