RegulonDB

Gene
Name:	flgH
Synonym(s):	ECK1064, G364, b1079, flaY
Genome position(nucleotides):	1135564 --> 1136262
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	53.51
External database links:

ASAP:	ABE-0003654
CGSC:	752
ECHOBASE:	EB4161
ECOLIHUB:	flgH
OU-MICROARRAY:	b1079
STRING:	511145.b1079
COLOMBOS:	flgH

Product

Name:

flagellar L-ring protein

Synonym(s):

FlaY, FlgH

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

outer membrane,cell projection

Molecular weight:

24.615

Isoelectric point:

8.434

Motif(s):

Type	Positions	Sequence	Comment
	1 -> 21	MQKNAAHTYAISSLLVLSLTG
	22 -> 232	CAWIPSTPLVQGATSAQPVPGPTPVANGSIFQSAQPINYGYQPLFEDRRPRNIGDTLTIVLQENVSASKSSSANASRDGKTNFGFDTVPRYLQGLFGNARADVEASGGNTFNGKGGANASNTFSGTLTVTVDQVLVNGNLHVVGEKQIAINQGTEFIRFSGVVNPRTISGSNTVPSTQVADARIEYVGNGYINEAQNMGWLQRFFLNLSPM	UniProt: Flagellar L-ring protein.
	47 -> 231	ANGSIFQSAQPINYGYQPLFEDRRPRNIGDTLTIVLQENVSASKSSSANASRDGKTNFGFDTVPRYLQGLFGNARADVEASGGNTFNGKGGANASNTFSGTLTVTVDQVLVNGNLHVVGEKQIAINQGTEFIRFSGVVNPRTISGSNTVPSTQVADARIEYVGNGYINEAQNMGWLQRFFLNLSP

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.12 - flagellum
		5 - cell processes --> 5.3 - motility, chemotaxis, energytaxis (aerotaxis, redoxtaxis etc)
		6 - cell structure --> 6.4 - flagella
Gene Ontology Terms (GO)
	cellular_component	GO:0009279 - cell outer membrane GO:0016020 - membrane GO:0009288 - bacterial-type flagellum GO:0009425 - bacterial-type flagellum basal body GO:0009427 - bacterial-type flagellum basal body, distal rod, L ring
	molecular_function	GO:0003774 - cytoskeletal motor activity
	biological_process	GO:0006970 - response to osmotic stress GO:0071973 - bacterial-type flagellum-dependent cell motility GO:0097588 - archaeal or bacterial-type flagellum-dependent cell motility

Note(s):

Note(s): ...[more].

Reference(s):

[1] Rao S., et al., 2020

External database links:

ALPHAFOLD:

P0A6S0

ECOCYC:

FLGH-FLAGELLAR-L-RING

ECOLIWIKI:

INTERPRO:

PANTHER:

PFAM:

PRIDE:

PRINTS:

PROSITE:

REFSEQ:

UNIPROT:

Operon

Name:

flgBCDEFGHIJ

Operon arrangement:

Transcription unit	Promoter
flgBCDEFGHIJ	flgBp

Transcriptional Regulation
	Display Regulation
Activated by:	FlhDC

RNA cis-regulatory element

Attenuation:	Transcriptional

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	TSS_1346	1137124		forward	nd	[RS-EPT-CBR]	[2]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Rao S., Bates GT., Matthews CR., Newport TD., Vickery ON., Stansfeld PJ., 2020, Characterizing Membrane Association and Periplasmic Transfer of Bacterial Lipoproteins through Molecular Dynamics Simulations., Structure 28(4):475-487.e3
[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

Reference(s)

[1] Rao S., Bates GT., Matthews CR., Newport TD., Vickery ON., Stansfeld PJ., 2020, Characterizing Membrane Association and Periplasmic Transfer of Bacterial Lipoproteins through Molecular Dynamics Simulations., Structure 28(4):475-487.e3

[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.