RegulonDB RegulonDB 11.1: Gene Form
   

flhA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

flhA flhB cheZ yecT flhE FlhDC FlhDC flhBp flhBp

Gene      
Name: flhA    Texpresso search in the literature
Synonym(s): ECK1880, G370, b1879, flaH
Genome position(nucleotides): 1962972 <-- 1965050
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.88
External database links:  
ASAP:
 ABE-0006272
CGSC:
 768
ECHOBASE:
 EB4021
ECOLIHUB:
 flhA
OU-MICROARRAY:
 b1879
STRING:
 511145.b1879
COLOMBOS: flhA


Product      
Name: flagellar biosynthesis protein FlhA
Synonym(s): FlaH, FlhA
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane,cell projection
Molecular weight: 74.843
Isoelectric point: 6.046
Motif(s):
 
Type Positions Sequence Comment
24 -> 44 GPILILLILSMMVLPLPAFIL UniProt: Helical.
31 -> 680 ILSMMVLPLPAFILDLLFTFNIALSIMVLLVAMFTQRTLEFAAFPTILLFTTLLRLALNVASTRIILMEGHTGAAAAGKVVEAFGHFLVGGNFAIGIVVFVILVIINFMVITKGAGRIAEVGARFVLDGMPGKQMAIDADLNAGLIGEDEAKKRRSEVTQEADFYGSMDGASKFVRGDAIAGILIMVINIVGGLLVGVLQHGMSMGHAAESYTLLTIGDGLVAQIPALVISTAAGVIVTRVSTDQDVGEQMVNQLFSNPSVMLLSAAVLGLLGLVPGMPNLVFLLFTAGLLGLAWWIRGREQKAPAEPKPVKMAENNTVVEATWNDVQLEDSLGMEVGYRLIPMVDFQQDGELLGRIRSIRKKFAQEMGFLPPVVHIRDNMDLQPARYRILMKGVEIGSGDAYPGRWLAINPGTAAGTLPGEATVDPAFGLNAIWIESALKEQAQIQGYTVVEASTVVATHLNHLISQHAAELFGRQEAQQLLDRVAQEMPKLTEDLVPGVVTLTTLHKVLQNLLDEKVPIRDMRTILETLAEHAPIQSDPHELTAVVRVALGRAITQQWFPGKDEVHVIGLDTPLERLLLQALQGGGGLEPGLADRLLAQTQEALSRQEMLGAPPVLLVNHALRPLLSRFLRRSLPQLVVLSNLELSDN
46 -> 66 LLFTFNIALSIMVLLVAMFTQ UniProt: Helical.
71 -> 91 FAAFPTILLFTTLLRLALNVA UniProt: Helical.
95 -> 115 IILMEGHTGAAAAGKVVEAFG UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.12 - flagellum
  5 - cell processes --> 5.3 - motility, chemotaxis, energytaxis (aerotaxis, redoxtaxis etc)
  6 - cell structure --> 6.1 - membrane
  6 - cell structure --> 6.4 - flagella
Gene Ontology Terms (GO)  
cellular_component GO:0120102 - bacterial-type flagellum secretion apparatus
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
GO:0009288 - bacterial-type flagellum
GO:0030257 - type III protein secretion system complex
molecular_function GO:0005515 - protein binding
biological_process GO:0015031 - protein transport
GO:0006935 - chemotaxis
GO:0009306 - protein secretion
GO:0030254 - protein secretion by the type III secretion system
GO:0071973 - bacterial-type flagellum-dependent cell motility
GO:0044780 - bacterial-type flagellum assembly
GO:0044781 - bacterial-type flagellum organization
Note(s): Note(s): ...[more].
Reference(s): [1] Li H., et al., 2011
External database links:  
ALPHAFOLD:
 P76298
ECOCYC:
 G370-MONOMER
ECOLIWIKI:
 b1879
INTERPRO:
 IPR042193
INTERPRO:
 IPR006301
INTERPRO:
 IPR042194
INTERPRO:
 IPR001712
INTERPRO:
 IPR025505
INTERPRO:
 IPR042196
PANTHER:
 PTHR30161
PFAM:
 PF00771
PRIDE:
 P76298
PRINTS:
 PR00949
PRODB:
 PRO_000022650
PROSITE:
 PS00994
REFSEQ:
 NP_416393
SMR:
 P76298
UNIPROT:
 P76298


Operon      
Name: flhBAE         
Operon arrangement:
Transcription unit        Promoter
flhBAE


Transcriptional Regulation      
Display Regulation             
Activated by: FlhDC


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Li H., Sourjik V., 2011, Assembly and stability of flagellar motor in Escherichia coli., Mol Microbiol 80(4):886-99

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