RegulonDB RegulonDB 11.2: Gene Form
   

citX gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

citF citT citG citX citTp4 citTp4 citTp6 citTp6

Gene      
Name: citX    Texpresso search in the literature
Synonym(s): ECK0607, G6340, b0614, ybdU
Genome position(nucleotides): 647484 <-- 648035
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 58.33
External database links:  
ASAP:
 ABE-0002116
ECHOBASE:
 EB3310
ECOLIHUB:
 citX
OU-MICROARRAY:
 b0614
STRING:
 511145.b0614
COLOMBOS: citX


Product      
Name: apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
Synonym(s): CitX, YbdU
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 20.27
Isoelectric point: 7.293
Motif(s):
 
Type Positions Sequence Comment
14 -> 175 SIPELLVSRDERQARQHVWLKRHPVPLVSFTVVAPGPIKDSEVTRRIFNHGVTALRALAAKQGWQIQEQAALVSASGPEGMLSIAAPARDLKLATIELEHSHPLGRLWDIDVLTPEGEILSRRDYSLPPRRCLLCEQSAAVCARGKTHQLTDLLNRMEALLN

 
Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.3 - protein related --> 2.3.3 - posttranslational modification
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0016779 - nucleotidyltransferase activity
GO:0016740 - transferase activity
GO:0050519 - holo-citrate lyase synthase activity
biological_process GO:0051191 - prosthetic group biosynthetic process
GO:0018247 - protein-phosphoribosyl dephospho-coenzyme A linkage
Note(s): Note(s): ...[more].
Reference(s): [1] Hoenke S., et al., 2000
External database links:  
ALPHAFOLD:
 P0A6G5
ECOCYC:
 G6340-MONOMER
ECOLIWIKI:
 b0614
INTERPRO:
 IPR005551
PFAM:
 PF03802
PRIDE:
 P0A6G5
PRODB:
 PRO_000022293
REFSEQ:
 NP_415147
UNIPROT:
 P0A6G5


Operon      
Name: citCDEFXG         
Operon arrangement:
Transcription unit        Promoter
citCDEFXG
citCDEFXG


Transcriptional Regulation      
Display Regulation             
Activated by: DpiA
Repressed by: CRP, FNR, ArcA, NarL


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter citTp6 646603 reverse nd [COMP-AINF] [2]
  promoter citTp4 646632 reverse nd [COMP-AINF] [2]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Hoenke S., Schmid M., Dimroth P., 2000, Identification of the active site of phosphoribosyl-dephospho-coenzyme A transferase and relationship of the enzyme to an ancient class of nucleotidyltransferases., Biochemistry 39(43):13233-40

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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