RegulonDB RegulonDB 10.8: Gene Form
   

hscC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

hscC djlC rihA ybeU hscCp7 hscCp7 hscCp5 hscCp5

Gene      
Name: hscC    Texpresso search in the literature
Synonym(s): ECK0643, G6357, b0650, ybeW
Genome position(nucleotides): 681723 <-- 683393 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 50.03
External database links:  
ASAP:
 ABE-0002225
ECHOBASE:
 EB3417
OU-MICROARRAY:
 b0650
PortEco:
 hscC
STRING:
 511145.b0650
COLOMBOS: hscC


Product      
Name: chaperone protein HscC
Synonym(s): Hsc62, Hsc62, Hsp70 family chaperone, binds to RpoD and inhibits transcription, HscC, YbeW
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 61.986
Isoelectric point: 4.813
Motif(s):
 
Type Positions Sequence
7 -> 540 AIGIDLGTTNSLIAVWKDGAAQLIPNKFGEYLTPSIISMDENNHILVGKPAVSRRTSHPDKTAALFKRAMGSNTNWRLGSDTFNAPELSSLVLRSLKEDAEEFLQRPIKDVVISVPAYFSDEQRKHTRLAAELAGLNAVRLINEPTAAAMAYGLHTQQNTRSLVFDLGGGTFDVTVLEYATPVIEVHASAGDNFLGGEDFTHMLVDEVLKRADVARTTLNESELAALYACVEAAKCSNQSPLHIRWQYQEETRECEFYENELEDLWLPLLNRLRVPIEQALRDARLKPSQIDSLVLVGGASQMPLVQRIAVRLFGKLPYQSYDPSTIVALGAAIQAACRLRSEDIEEVILTDICPYSLGVEVNRQGVSGIFSPIIERNTTVPVSRVETYSTMHPEQDSITVNVYQGENHKVKNNILVESFDVPLKKTGAYQSIDIRFSYDINGLLEVDVLLEDGSVKSRVINHSPVTLSAQQIEESRTRLSALKIYPRDMLINRTFKAKLEELWARALGDEREEIGRVITDFDAALQSNDMARV

 
Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.3 - protein related --> 2.3.4 - chaperoning, repair (refolding)
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0051787 - misfolded protein binding
GO:0005515 - protein binding
GO:0016887 - ATPase activity
GO:0051082 - unfolded protein binding
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0031072 - heat shock protein binding
GO:0044183 - protein folding chaperone
biological_process GO:0006950 - response to stress
GO:0042026 - protein refolding
GO:0051085 - chaperone cofactor-dependent protein refolding
GO:0006986 - response to unfolded protein
GO:0034620 - cellular response to unfolded protein
Note(s): Note(s): ...[more].
Evidence: [IE] Inferred from experiment
External database links:  
DIP:
 DIP-9942N
ECOCYC:
 G6357-MONOMER
ECOLIWIKI:
 b0650
INTERPRO:
 IPR042030
INTERPRO:
 IPR029047
INTERPRO:
 IPR018181
INTERPRO:
 IPR013126
MODBASE:
 P77319
PANTHER:
 PTHR19375
PFAM:
 PF00012
PRIDE:
 P77319
PRINTS:
 PR00301
PRODB:
 PRO_000022927
PROSITE:
 PS00297
PROSITE:
 PS00329
PROSITE:
 PS01036
REFSEQ:
 NP_415183
SMR:
 P77319
UNIPROT:
 P77319


Operon      
Name: hscC         
Operon arrangement:
Transcription unit        Promoter
 


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter hscCp5 683482 reverse Similarity to the consensus
Read more > 		[ICWHO] [1]
  promoter hscCp7 683594 reverse Similarity to the consensus
Read more > 		[ICWHO] [1]


Evidence    

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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