RegulonDB RegulonDB 11.1: Gene Form
   

modE gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

modF modE acrZ SoxS Rob MarA anti-anti-terminator anti-terminator anti-terminator terminator acrZp acrZp

Gene      
Name: modE    Texpresso search in the literature
Synonym(s): ECK0750, G6395, b0761, chlD, modR
Genome position(nucleotides): 793856 <-- 794644
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.6
External database links:  
ASAP:
 ABE-0002585
ECHOBASE:
 EB3017
ECOLIHUB:
 modE
OU-MICROARRAY:
 b0761
STRING:
 511145.b0761
COLOMBOS: modE


Product      
Name: DNA-binding transcriptional dual regulator ModE
Synonym(s): ChlD, ModE, ModE-MoO42-, ModR
Sequence: Get amino acid sequence Fasta Format
Regulator Family: LysR
Cellular location: cytosol
Molecular weight: 28.281
Isoelectric point: 5.08
Motif(s):
 
Type Positions Sequence Comment
1 -> 121 MQAEILLTLKLQQKLFADPRRISLLKHIALSGSISQGAKDAGISYKSAWDAINEMNQLSEHILVERATGGKGGGGAVLTRYGQRLIQLYDLLAQIQQKAFDVLSDDDALPLNSLLAAISRF UniProt: I; Sequence Annotation Type: region of interest.
20 -> 83 RRISLLKHIALSGSISQGAKDAGISYKSAWDAINEMNQLSEHILVERATGGKGGGGAVLTRYGQ
33 -> 79 SISQGAKDAGISYKSAWDAINEMNQLSEHILVERATGGKGGGGAVLT UniProt: H-T-H motif.
76 -> 76 A UniProt: Partial loss of repression by ModE..
124 -> 191 QTSARNQWFGTITARDHDDVQQHVDVLLADGKTRLKVAITAQSGARLGLDEGKEVLILLKAPWVGITQ UniProt: Mop 1.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.4 - molybdenum
  2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
  3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.2 - activator
  3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.3 - repressor
  3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
Gene Ontology Terms (GO)  
cellular_component GO:1990198 - ModE complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0003677 - DNA binding
GO:0046872 - metal ion binding
GO:0003700 - DNA-binding transcription factor activity
GO:0030151 - molybdenum ion binding
GO:0000987 - cis-regulatory region sequence-specific DNA binding
biological_process GO:0006355 - regulation of transcription, DNA-templated
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0045893 - positive regulation of transcription, DNA-templated
GO:0015689 - molybdate ion transport
GO:2000143 - negative regulation of DNA-templated transcription, initiation
External database links:  
ALPHAFOLD:
 P0A9G8
DIP:
 DIP-10238N
ECOCYC:
 MONOMER0-185
ECOLIWIKI:
 b0761
INTERPRO:
 IPR004606
INTERPRO:
 IPR036390
INTERPRO:
 IPR000847
INTERPRO:
 IPR005116
INTERPRO:
 IPR008995
INTERPRO:
 IPR016462
INTERPRO:
 IPR036388
INTERPRO:
 IPR003725
MODBASE:
 P0A9G8
PDB:
 1B9M
PDB:
 1B9N
PDB:
 1H9R
PDB:
 1H9S
PDB:
 1O7L
PFAM:
 PF03459
PFAM:
 PF00126
PRIDE:
 P0A9G8
PRODB:
 PRO_000023270
PROSITE:
 PS51866
REFSEQ:
 NP_415282
SMR:
 P0A9G8
UNIPROT:
 P0A9G8


Operon      
Name: modEF         
Operon arrangement:
Transcription unit        Promoter
modEF


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



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