RegulonDB RegulonDB 10.8: Gene Form
   

zapC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

rlmL ycbX pyrD zapC Cis-reg; leader terminator anti-terminator terminator TSS_1248 TSS_1248 rlmLp rlmLp ycbWp4 ycbWp4 TSS_1247 (cluster) TSS_1247 (cluster) ycbWp6 ycbWp6

Gene      
Name: zapC    Texpresso search in the literature
Synonym(s): ECK0937, G6486, b0946, ycbW
Genome position(nucleotides): 1005952 --> 1006494 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
49.36
External database links:  
ASAP:
ABE-0003204
ECHOBASE:
EB3479
OU-MICROARRAY:
b0946
PortEco:
ycbW
STRING:
511145.b0946
COLOMBOS: zapC


Product      
Name: cell division protein ZapC
Synonym(s): YcbW, ZapC
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 20.589
Isoelectric point: 5.041
Motif(s):
 
Type Positions Sequence
3 -> 168 IKPDDNWRWYYDEEHDRMMLDLANGMLFRSRFARKMLTPDAFSPAGFCVDDAALYFSFEEKCRDFNLSKEQKAELVLNALVAIRYLKPQMPKSWHFVSHGEMWVPMPGDAACVWLSDTHEQVNLLVVESGENAALCLLAQPCVVIAGRAMQLGDAIKIMNDRLKPQ
22 -> 22 L

 

Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.1 - cell division
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0032153 - cell division site
molecular_function GO:0005515 - protein binding
GO:0042802 - identical protein binding
biological_process GO:0036212 - contractile ring maintenance
GO:0051301 - cell division
GO:0007049 - cell cycle
GO:0051302 - regulation of cell division
GO:0043093 - FtsZ-dependent cytokinesis
GO:0000917 - division septum assembly
GO:0090529 - cell septum assembly
Note(s): Note(s): ...[more].
Evidence: [IGI] Inferred from genetic interaction
[IPI] Inferred from physical interaction
Reference(s): [1] Durand-Heredia JM., et al., 2011
[2] Hale CA., et al., 2011
[3] Krupka M., et al., 2017
External database links:  
DIP:
DIP-11485N
ECOCYC:
G6486-MONOMER
ECOLIWIKI:
b0946
INTERPRO:
IPR009809
MINT:
P75862
PDB:
5E1L
PDB:
5FO3
PFAM:
PF07126
PRIDE:
P75862
REFSEQ:
NP_415466
SMR:
P75862
UNIPROT:
P75862


Operon      
Name: zapC         
Operon arrangement:
Transcription unit        Promoter
 


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter ycbWp6 1005850 forward Similarity to the consensus
Read more >
[ICWHO] [4]
  promoter TSS_1247 (cluster) 1005852 forward For this promoter, there
Read more >
[RS-EPT-CBR] [5]
  promoter ycbWp4 1005890 forward Similarity to the consensus
Read more >
[ICWHO] [4]
  promoter TSS_1248 1008970 forward nd [RS-EPT-CBR] [5]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Durand-Heredia JM., Yu HH., De Carlo S., Lesser CF., Janakiraman A., 2011, Identification and characterization of ZapC, a stabilizer of the FtsZ ring in Escherichia coli., J Bacteriol 193(6):1405-13

 [2] Hale CA., Shiomi D., Liu B., Bernhardt TG., Margolin W., Niki H., de Boer PA., 2011, Identification of Escherichia coli ZapC (YcbW) as a component of the division apparatus that binds and bundles FtsZ polymers., J Bacteriol 193(6):1393-404

 [3] Krupka M., Rowlett VW., Morado D., Vitrac H., Schoenemann K., Liu J., Margolin W., 2017, Escherichia coli FtsA forms lipid-bound minirings that antagonize lateral interactions between FtsZ protofilaments., Nat Commun 8:15957

 [4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [5] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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