RegulonDB

Gene
Name:	rutF
Synonym(s):	ECK0998, G6518, b1007, ycdH
Genome position(nucleotides):	1069860 <-- 1070354 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	58.99
External database links:

ASAP:	ABE-0003403
ECHOBASE:	EB3614
OU-MICROARRAY:	b1007
PortEco:	rutF
STRING:	511145.b1007
COLOMBOS:	rutF

Product

Name:

flavin reductase

Synonym(s):

RutF, YcdH

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

17.749

Isoelectric point:

6.649

Motif(s):

Type	Positions	Sequence
	13 -> 159	MSCMGAAVNIITTDGPAGRAGFTASAVCSVTDTPPTLLVCLNRGASVWPAFNENRTLCVNTLSAGQEPLSNLFGGKTPMEHRFAAARWQTGVTGCPQLEEALVSFDCRISQVVSVGTHDILFCAIEAIHRHTTPYGLVWFDRSYHAL

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		1 - metabolism --> 1.8 - metabolism of other compounds --> 1.8.3 - nitrogen metabolism
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0016491 - oxidoreductase activity GO:0016646 - oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor GO:0008752 - FMN reductase activity GO:0048037 - cofactor binding GO:0010181 - FMN binding GO:0042602 - riboflavin reductase (NADPH) activity
	biological_process	GO:0006208 - pyrimidine nucleobase catabolic process GO:0019740 - nitrogen utilization GO:0055114 - oxidation-reduction process GO:0006212 - uracil catabolic process

Note(s):

Note(s): ...[more].

Evidence:

[HIFS] Human inference of function from sequence
[IEP] Inferred from expression pattern
[IMP] Inferred from mutant phenotype

Reference(s):

[1] Loh KD., et al., 2006
[2] Zimmer DP., et al., 2000

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PFAM:

PRIDE:

REFSEQ:

SMART:

SMR:

UNIPROT:

Operon

Name:

rutABCDEFG

Operon arrangement:

Transcription unit	Promoter
rutABCDEFG	rutAp

Transcriptional Regulation
	Display Regulation
Activated by:	PhoP, NtrC, ArcA
Repressed by:	RutR

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	rutGp2	1070045		reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.456. P-value: 3.466e-5 Read more >	[ICWHO]	[3]

Evidence
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Loh KD., Gyaneshwar P., Markenscoff Papadimitriou E., Fong R., Kim KS., Parales R., Zhou Z., Inwood W., Kustu S., 2006, A previously undescribed pathway for pyrimidine catabolism., Proc Natl Acad Sci U S A 103(13):5114-9
[2] Zimmer DP., Soupene E., Lee HL., Wendisch VF., Khodursky AB., Peter BJ., Bender RA., Kustu S., 2000, Nitrogen regulatory protein C-controlled genes of Escherichia coli: scavenging as a defense against nitrogen limitation., Proc Natl Acad Sci U S A 97(26):14674-9
[3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78