RegulonDB

Gene
Name:	patD
Synonym(s):	ECK1438, G6755, b1444, prr, ydcW
Genome position(nucleotides):	1515578 --> 1517002
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	53.19
External database links:

ASAP:	ABE-0004813
ECHOBASE:	EB3529
ECOLIHUB:	ydcW
OU-MICROARRAY:	b1444
STRING:	511145.b1444
COLOMBOS:	patD

Product

Name:

γ-aminobutyraldehyde dehydrogenase

Synonym(s):

PatD, Prr, YdcW

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

50.83

Isoelectric point:

5.893

Motif(s):

Type	Positions	Sequence	Comment
	13 -> 470	SGEGEKQPVYNPATGDVLLEIAEASAEQVDAAVRAADAAFAEWGQTTPKVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNGLAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDIFPAGVINILFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTASSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVGKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHV
	146 -> 148	APW	UniProt: NAD.
	172 -> 175	KPSE	UniProt: NAD.
	225 -> 228	SIAT	UniProt: NAD.

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		1 - metabolism --> 1.8 - metabolism of other compounds --> 1.8.3 - nitrogen metabolism
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol GO:0032991 - protein-containing complex
	molecular_function	GO:0016491 - oxidoreductase activity GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0019145 - aminobutyraldehyde dehydrogenase activity GO:0042802 - identical protein binding GO:0051287 - NAD binding GO:0004029 - aldehyde dehydrogenase (NAD+) activity GO:0033737 - 1-pyrroline dehydrogenase activity
	biological_process	GO:0009447 - putrescine catabolic process GO:0051289 - protein homotetramerization GO:0019477 - L-lysine catabolic process

Note(s):

Note(s): ...[more].

Reference(s):

[1] Jorge JM., et al., 2016
[2] Jorge JM., et al., 2017
[3] Knorr S., et al., 2018
[4] Perez-Garcia F., et al., 2018

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

ECOO157CYC:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PANTHER:

PDB:

PDB:

PFAM:

PRIDE:

PROSITE:

REFSEQ:

SMR:

UNIPROT:

Transcriptional Regulation
	Display Regulation
Activated by:	Nac

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	patDp3	1515415		forward	nd	[COMP-AINF]	[5]
	promoter	patDp4	1515440		forward	nd	[COMP-AINF]	[5]

Reference(s)
[1] Jorge JM., Leggewie C., Wendisch VF., 2016, A new metabolic route for the production of gamma-aminobutyric acid by Corynebacterium glutamicum from glucose., Amino Acids 48(11):2519-2531
[2] Jorge JM., Nguyen AQ., Perez-Garcia F., Kind S., Wendisch VF., 2017, Improved fermentative production of gamma-aminobutyric acid via the putrescine route: Systems metabolic engineering for production from glucose, amino sugars, and xylose., Biotechnol Bioeng 114(4):862-873
[3] Knorr S., Sinn M., Galetskiy D., Williams RM., Wang C., Muller N., Mayans O., Schleheck D., Hartig JS., 2018, Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate., Nat Commun 9(1):5071
[4] Perez-Garcia F., Jorge JMP., Dreyszas A., Risse JM., Wendisch VF., 2018, Efficient Production of the Dicarboxylic Acid Glutarate by Corynebacterium glutamicum via a Novel Synthetic Pathway., Front Microbiol 9:2589
[5] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78