Gene
Name:	zinT
Synonym(s):	ECK1969, G7061, b1973, yodA
Genome position(nucleotides):	2041375 --> 2042025 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	38.25
External database links:

ASAP:	ABE-0006546
ECHOBASE:	EB3802
OU-MICROARRAY:	b1973
PortEco:	zinT
STRING:	511145.b1973
COLOMBOS:	zinT

Transcriptional Regulation
	Display Regulation
Activated by:	Fur, OxyR, SoxS
Repressed by:	Zur

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_2282	2041344	forward	nd	[RS-EPT-CBR]	[7]
promoter	yodBp15	2042176	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 5.315. P-value: 4.632e-5 Read more >	[ICWHO]	[8]
promoter	yodBp14	2042261	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: poor homology. Score: 4.816. P-value: 3.136e-5 Read more >	[ICWHO]	[8]
promoter	yodBp16	2042294	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 5.535. P-value: 1.637e-5 Read more >	[ICWHO]	[8]
promoter	yodBp13	2042308	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 4.419. P-value: 4.406e-5 Read more >	[ICWHO]	[8]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] David G., Blondeau K., Renouard M., Lewit-Bentley A., 2002, Crystallization and preliminary analysis of Escherichia coli YodA., Acta Crystallogr D Biol Crystallogr 58(Pt 7):1243-5
[2] David G., Blondeau K., Schiltz M., Penel S., Lewit-Bentley A., 2003, YodA from Escherichia coli is a metal-binding, lipocalin-like protein., J Biol Chem 278(44):43728-35
[3] Gabbianelli R., Scotti R., Ammendola S., Petrarca P., Nicolini L., Battistoni A., 2011, Role of ZnuABC and ZinT in Escherichia coli O157:H7 zinc acquisition and interaction with epithelial cells., BMC Microbiol 11:36
[4] Graham AI., Hunt S., Stokes SL., Bramall N., Bunch J., Cox AG., McLeod CW., Poole RK., 2009, Severe Zinc Depletion of Escherichia coli: roles for high affinity zinc binding by ZinT, zinc transport and zinc-independent proteins., J Biol Chem 284(27):18377-89
[5] Hantke K., 2005, Bacterial zinc uptake and regulators., Curr Opin Microbiol 8(2):196-202
[6] Kannan G., Wilks JC., Fitzgerald DM., Jones BD., Bondurant SS., Slonczewski JL., 2008, Rapid acid treatment of Escherichia coli: transcriptomic response and recovery., BMC Microbiol 8:37
[7] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[8] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78