RegulonDB RegulonDB 11.1: Gene Form
   

wcaD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

wcaD wcaC wcaE wcaB

Gene      
Name: wcaD    Texpresso search in the literature
Synonym(s): ECK2050, G7101, b2056
Genome position(nucleotides): 2129661 <-- 2130878
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 42.04
External database links:  
ASAP:
 ABE-0006809
ECHOBASE:
 EB3342
ECOLIHUB:
 wcaD
OU-MICROARRAY:
 b2056
STRING:
 511145.b2056
COLOMBOS: wcaD


Product      
Name: colanic acid polymerase
Synonym(s): WcaD
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 45.409
Isoelectric point: 10.014
Motif(s):
 
Type Positions Sequence Comment
5 -> 25 IRICSYLLLPLIYLLVNVKIA UniProt: Helical.
27 -> 47 LGESFPITIVTFLPVLLLLFL UniProt: Helical.
55 -> 75 LMIALGIGAGLTAFNYLFGQS UniProt: Helical.
81 -> 101 YVTSTMLFVYIVIIIGMVWSI UniProt: Helical.
108 -> 108 P UniProt: In Ref. 2; AAC77839..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.2 - colanic acid (M antigen)
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
biological_process GO:0009103 - lipopolysaccharide biosynthetic process
GO:0046377 - colanic acid metabolic process
GO:0045228 - slime layer polysaccharide biosynthetic process
Note(s): Note(s): ...[more].
Reference(s): [1] Mao Y., et al., 2001
External database links:  
ALPHAFOLD:
 P71238
DIP:
 DIP-11120N
ECOCYC:
 G7101-MONOMER
ECOLIWIKI:
 b2056
INTERPRO:
 IPR024013
PRIDE:
 P71238
REFSEQ:
 NP_416560
UNIPROT:
 P71238


Operon      
Name: wcaCDEF-gmd-fcl-gmm-wcaI-cpsBG-wcaJ-wzxC         
Operon arrangement:
Transcription unit        Promoter
wcaCDEF-gmd-fcl-gmm-wcaI-cpsBG-wcaJ-wzxC


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Mao Y., Doyle MP., Chen J., 2001, Insertion mutagenesis of wca reduces acid and heat tolerance of enterohemorrhagic Escherichia coli O157:H7., J Bacteriol 183(12):3811-5

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