RegulonDB

Gene
Name:	pmrD
Synonym(s):	ECK2253, G7172, b2259
Genome position(nucleotides):	2373272 <-- 2373538 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	46.82
External database links:

ASAP:	ABE-0007468
ECHOBASE:	EB2537
OU-MICROARRAY:	b2259
PortEco:	pmrD
STRING:	511145.b2259
COLOMBOS:	pmrD

Product

Name:

signal transduction protein PmrD

Synonym(s):

PmrD, polymyxin B resistance protein

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

9.87

Isoelectric point:

8.492

Motif(s):

Type	Positions	Sequence
	82 -> 82	K
	1 -> 82	MEWLVKKSCCNKQDNRHVLMLCDAGGAIKMIAEVKSDFAVKVGDLLSPLQNALYCINREKLHTVKVLSASSYSPDEWERQCK
	20 -> 20	M
	88 -> 88	Q
	19 -> 19	L

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		5 - cell processes --> 5.6 - protection --> 5.6.4 - drug resistance/sensitivity
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	biological_process	GO:0046677 - response to antibiotic

Note(s):

Note(s): ...[more].

Reference(s):

[1] Herrera CM., et al., 2010
[2] Jo H., et al., 2014

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

PDB:

PDB:

PFAM:

PRIDE:

PRODB:

PRODOM:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

pmrD

Operon arrangement:

Transcription unit	Promoter

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	pmrDp4	2373566		reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.963. P-value: 1.086e-5 Read more >	[ICWHO]	[3]
	promoter	pmrDp3	2373574		reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.814. P-value: 5.119e-5 Read more >	[ICWHO]	[3]

Reference(s)
[1] Herrera CM., Hankins JV., Trent MS., 2010, Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides., Mol Microbiol 76(6):1444-60
[2] Jo H., Jeong E., Jeon J., Ban C., 2014, Structural insights into Escherichia coli polymyxin B resistance protein D with X-ray crystallography and small-angle X-ray scattering., BMC Struct Biol 14(1):24
[3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78