RegulonDB RegulonDB 11.1: Gene Form
   

frc gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

oxc frc yfdX EvgA terminator frcp frcp oxcp11 oxcp11 oxcp10 oxcp10

Gene      
Name: frc    Texpresso search in the literature
Synonym(s): ECK2370, G7237, b2374, yfdW
Genome position(nucleotides): 2492004 <-- 2493254
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 47.08
External database links:  
ASAP:
 ABE-0007828
ECHOBASE:
 EB3897
ECOLIHUB:
 frc
OU-MICROARRAY:
 b2374
STRING:
 511145.b2374
COLOMBOS: frc


Product      
Name: formyl-CoA transferase
Synonym(s): Frc, YfdW
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 45.828
Isoelectric point: 5.283
Motif(s):
 
Type Positions Sequence Comment
5 -> 393 LQGIKVLDFTGVQSGPSCTQMLAWFGADVIKIERPGVGDVTRHQLRDIPDIDALYFTMLNSNKRSIELNTKTAEGKEVMEKLIREADILVENFHPGAIDHMGFTWEHIQEINPRLIFGSIKGFDECSPYVNVKAYENVAQAAGGAASTTGFWDGPPLVSAAALGDSNTGMHLLIGLLAALLHREKTGRGQRVTMSMQDAVLNLCRVKLRDQQRLDKLGYLEEYPQYPNGTFGDAVPRGGNAGGGGQPGWILKCKGWETDPNAYIYFTIQEQNWENTCKAIGKPEWITDPAYSTAHARQPHIFDIFAEIEKYTVTIDKHEAVAYLTQFDIPCAPVLSMKEISLDPSLRQSGSVVEVEQPLRGKYLTVGCPMKFSAFTPDIKAAPLLGEHT
17 -> 18 QS UniProt: Coenzyme A binding; Sequence Annotation Type: region of interest.
72 -> 75 LNTK UniProt: Coenzyme A binding; Sequence Annotation Type: region of interest.
96 -> 98 NFH UniProt: Coenzyme A binding; Sequence Annotation Type: region of interest.
137 -> 140 KAYE UniProt: Coenzyme A binding; Sequence Annotation Type: region of interest.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.8 - metabolism of other compounds
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016740 - transferase activity
GO:0008410 - CoA-transferase activity
GO:0033608 - formyl-CoA transferase activity
biological_process GO:0033611 - oxalate catabolic process
GO:0071468 - cellular response to acidic pH
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P69902
ECOCYC:
 G7237-MONOMER
ECOLIWIKI:
 b2374
INTERPRO:
 IPR003673
INTERPRO:
 IPR023606
INTERPRO:
 IPR017659
MODBASE:
 P69902
PDB:
 1Q7E
PDB:
 1Q6Y
PDB:
 1PT8
PDB:
 1PT7
PDB:
 1PQY
PDB:
 1PT5
PFAM:
 PF02515
PRIDE:
 P69902
PRODB:
 PRO_000022685
REFSEQ:
 NP_416875
SMR:
 P69902
UNIPROT:
 P69902


Operon      
Name: yfdX-frc-oxc-yfdVE         
Operon arrangement:
Transcription unit        Promoter
frc
yfdX
oxc
yfdE
yfdV


Transcriptional Regulation      
Display Regulation             
Activated by: EvgA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter oxcp10 2492130 reverse nd [COMP-AINF] [1]
  promoter oxcp11 2492144 reverse nd [COMP-AINF] [1]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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