RegulonDB RegulonDB 11.1: Gene Form
   

kbp gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

glaR kbp yqaE TSS_2988 TSS_2988 kbpp4 kbpp4 TSS_2987 TSS_2987

Gene      
Name: kbp    Texpresso search in the literature
Synonym(s): ECK2659, G7395, b2665, ygaU, yzzM
Genome position(nucleotides): 2796337 <-- 2796786
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 48.44
External database links:  
ASAP:
 ABE-0008767
ECHOBASE:
 EB2540
ECOLIHUB:
 ygaU
OU-MICROARRAY:
 b2665
STRING:
 511145.b2665
COLOMBOS: kbp


Product      
Name: K+ binding protein
Synonym(s): Kbp, YgaU, YzzM
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 16.063
Isoelectric point: 5.779
Motif(s):
 
Type Positions Sequence Comment
2 -> 149 GLFNFVKDAGEKLWDAVTGQHDKDDQAKKVQEHLNKTGIPDADKVNIQIADGKATVTGDGLSQEAKEKILVAVGNISGIASVDDQVKTATPATASQFYTVKSGDTLSAISKQVYGNANLYNKIFEANKPMLKSPDKIYPGQVLRIPEE UniProt: Potassium binding protein Kbp.
23 -> 91 DKDDQAKKVQEHLNKTGIPDADKVNIQIADGKATVTGDGLSQEAKEKILVAVGNISGIASVDDQVKTAT UniProt: BON.
24 -> 89 KDDQAKKVQEHLNKTGIPDADKVNIQIADGKATVTGDGLSQEAKEKILVAVGNISGIASVDDQVKT
97 -> 146 QFYTVKSGDTLSAISKQVYGNANLYNKIFEANKPMLKSPDKIYPGQVLRI UniProt: LysM.
99 -> 147 YTVKSGDTLSAISKQVYGNANLYNKIFEANKPMLKSPDKIYPGQVLRIP

 
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.5 - adaptations --> 5.5.1 - osmotic pressure
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
molecular_function GO:0030955 - potassium ion binding
biological_process GO:0035864 - response to potassium ion
Note(s): Note(s): ...[more].
Evidence: [EXP-IDA] Inferred from direct assay
Reference(s): [1] Ashraf KU., et al., 2016
External database links:  
ALPHAFOLD:
 P0ADE6
DIP:
 DIP-48134N
ECOCYC:
 G7395-MONOMER
ECOLIWIKI:
 b2665
INTERPRO:
 IPR014004
INTERPRO:
 IPR036779
INTERPRO:
 IPR018392
INTERPRO:
 IPR007055
PDB:
 5FIM
PFAM:
 PF04972
PFAM:
 PF01476
PRIDE:
 P0ADE6
PROSITE:
 PS51782
PROSITE:
 PS50914
REFSEQ:
 NP_417151
SMART:
 SM00749
SMART:
 SM00257
SMR:
 P0ADE6
UNIPROT:
 P0ADE6


Operon      
Name: yqaE-kbp         
Operon arrangement:
Transcription unit        Promoter
kbp
yqaE
yqaE-kbp


Transcriptional Regulation      
Display Regulation             
Activated by: CpxR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2987 2796813 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2988 2796815 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Ashraf KU., Josts I., Mosbahi K., Kelly SM., Byron O., Smith BO., Walker D., 2016, The Potassium Binding Protein Kbp Is a Cytoplasmic Potassium Sensor., Structure 24(5):741-9

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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