RegulonDB RegulonDB 11.1: Gene Form
   

ftsB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ispD ygbE ftsB TSS_3038 TSS_3038 TSS_3037 TSS_3037 ftsBp ftsBp TSS_3036 TSS_3036 ispFp3 ispFp3 ispFp2 ispFp2

Gene      
Name: ftsB    Texpresso search in the literature
Synonym(s): ECK2743, G7424, b2748, ygbQ
Genome position(nucleotides): 2872509 <-- 2872820
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.92
External database links:  
ASAP:
 ABE-0009019
ECHOBASE:
 EB2914
ECOLIHUB:
 ftsB
OU-MICROARRAY:
 b2748
STRING:
 511145.b2748
COLOMBOS: ftsB


Product      
Name: cell division protein FtsB
Synonym(s): FtsB, YgbQ, essential cell division protein FtsB
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol,inner membrane
Molecular weight: 11.622
Isoelectric point: 7.527
Motif(s):
 
Type Positions Sequence Comment
4 -> 21 LTLLLLAILVWLQYSLWF UniProt: Helical.
11 -> 89 ILVWLQYSLWFGKNGIHDYTRVNDDVAAQQATNAKLKARNDQLFAEIDDLNGGQEALEERARNELSMTRPGETFYRLVP
41 -> 72 ATNAKLKARNDQLFAEIDDLNGGQEALEERAR UniProt: Leucine zipper-like; Sequence Annotation Type: short sequence motif.

 
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.1 - cell division
Gene Ontology Terms (GO)  
cellular_component GO:1990586 - divisome complex
GO:1990587 - FtsQBL complex
GO:1990588 - FtsBL complex
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0032153 - cell division site
GO:0030428 - cell septum
molecular_function GO:0005515 - protein binding
GO:0042802 - identical protein binding
biological_process GO:0051301 - cell division
GO:0007049 - cell cycle
GO:0043093 - FtsZ-dependent cytokinesis
GO:0000917 - division septum assembly
Note(s): Note(s): ...[more].
Evidence: [EXP-IMP] Inferred from mutant phenotype
Reference(s): [1] Buddelmeijer N., et al., 2002
[2] Khadria AS., et al., 2013
[3] Svanberg Frisinger F., et al., 2021
External database links:  
ALPHAFOLD:
 P0A6S5
DIP:
 DIP-12117N
ECOCYC:
 G7424-MONOMER
ECOLIWIKI:
 b2748
INTERPRO:
 IPR007060
INTERPRO:
 IPR023081
PANTHER:
 PTHR37485
PDB:
 5Z2W
PDB:
 4IFF
PFAM:
 PF04977
PRIDE:
 P0A6S5
PRODB:
 PRO_000022715
REFSEQ:
 NP_417228
SMR:
 P0A6S5
UNIPROT:
 P0A6S5


Operon      
Name: ftsB         
Operon arrangement:
Transcription unit        Promoter
ftsB


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter ispFp2 2871911 reverse nd [COMP-AINF] [4]
  promoter ispFp3 2871984 reverse nd [COMP-AINF] [4]
  promoter TSS_3036 2872900 reverse nd [RS-EPT-CBR] [5]
  promoter ftsBp 2872901 reverse nd [COMP-AINF], [COMP-AINF-POSITIONAL-IDENTIFICATION] [4], [6]
  promoter TSS_3037 2872957 reverse nd [RS-EPT-CBR] [5]
  promoter TSS_3038 2872975 reverse nd [RS-EPT-CBR] [5]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF-POSITIONAL-IDENTIFICATION] Automated inference of promoter position


Reference(s)    

 [1] Buddelmeijer N., Judson N., Boyd D., Mekalanos JJ., Beckwith J., 2002, YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site., Proc Natl Acad Sci U S A 99(9):6316-21

 [2] Khadria AS., Senes A., 2013, The transmembrane domains of the bacterial cell division proteins FtsB and FtsL form a stable high-order oligomer., Biochemistry 52(43):7542-50

 [3] Svanberg Frisinger F., Jana B., Donadio S., Guardabassi L., 2021, In Silico Prediction and Prioritization of Novel Selective Antimicrobial Drug Targets in Escherichia coli., Antibiotics (Basel) 10(6)

 [4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [5] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [6] Gama-Castro S., Jimenez-Jacinto V., Peralta-Gil M., Santos-Zavaleta A., Penaloza-Spinola MI., Contreras-Moreira B., Segura-Salazar J., Muniz-Rascado L., Martinez-Flores I., Salgado H., Bonavides-Martinez C., Abreu-Goodger C., Rodriguez-Penagos C., Miranda-Rios J., Morett E., Merino E., Huerta AM., Trevino-Quintanilla L., Collado-Vides J., 2008, RegulonDB (version 6.0): gene regulation model of Escherichia coli K-12 beyond transcription, active (experimental) annotated promoters and Textpresso navigation., Nucleic Acids Res 36(Database issue):D120-4

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