RegulonDB RegulonDB 11.1: Gene Form
   

patA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

aer patA ygjH Fis NtrC NtrC IHF FNR CRP NtrC patAp2 patAp2 patAp patAp aerp aerp TSS_3379 TSS_3379

Gene      
Name: patA    Texpresso search in the literature
Synonym(s): ECK3063, G7596, b3073, oat, pat, ygjG
Genome position(nucleotides): 3219494 --> 3220873
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.29
External database links:  
ASAP:
 ABE-0010092
ECHOBASE:
 EB2577
ECOLIHUB:
 ygjG
OU-MICROARRAY:
 b3073
STRING:
 511145.b3073
COLOMBOS: patA


Product      
Name: putrescine aminotransferase
Synonym(s): Oat, Pat, PatA, YgjG
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 49.661
Isoelectric point: 6.427
Motif(s):
 
Type Positions Sequence Comment
74 -> 449 NTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQNQLAKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFCNSGTESVEAALKLAKAYQSPRGKFTFIATSGAFHGKSLGALSATAKSTFRKPFMPLLPGFRHVPFGNIEAMRTALNECKKTGDDVAAVILEPIQGEGGVILPPPGYLTAVRKLCDEFGALMILDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGVMPIGATIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLPAQAEQKGDMLLDGFRQLAREYPDLVQEARGKGMLMAIEFVDNEIGYNFASEMFRQRVLVAGTLNNAKTIRIEPPLTLTIEQCELVIKAARKAL
150 -> 151 GT UniProt: Pyridoxal phosphate binding; Sequence Annotation Type: region of interest.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.8 - metabolism of other compounds --> 1.8.3 - nitrogen metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0019161 - diamine transaminase activity
GO:0003824 - catalytic activity
GO:0016740 - transferase activity
GO:0008483 - transaminase activity
GO:0030170 - pyridoxal phosphate binding
GO:0033094 - butane-1,4-diamine:2-oxoglutarate aminotransferase activity
GO:0042802 - identical protein binding
GO:0042803 - protein homodimerization activity
biological_process GO:0009447 - putrescine catabolic process
GO:0019477 - L-lysine catabolic process
External database links:  
ALPHAFOLD:
 P42588
DIP:
 DIP-12233N
ECOCYC:
 G7596-MONOMER
ECOLIWIKI:
 b3073
INTERPRO:
 IPR015422
INTERPRO:
 IPR015421
INTERPRO:
 IPR005814
INTERPRO:
 IPR017747
INTERPRO:
 IPR015424
MINT:
 P42588
MODBASE:
 P42588
PDB:
 4UOX
PDB:
 4UOY
PDB:
 5H7D
PDB:
 5X3F
PFAM:
 PF00202
PRIDE:
 P42588
PRODB:
 PRO_000023495
PROSITE:
 PS00600
REFSEQ:
 NP_417544
SMR:
 P42588
SWISSMODEL:
 P42588
UNIPROT:
 P42588


Operon      
Name: patA         
Operon arrangement:
Transcription unit        Promoter
patA
patA


Transcriptional Regulation      
Display Regulation             
Activated by: NtrC
Undetermined regulation Fis, IHF, IHF


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3379 3219118 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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