RegulonDB RegulonDB 11.1: Gene Form
   

yhaV gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

garD agaR yhaV prlF TSS_3410 (cluster) TSS_3410 (cluster) sohAp sohAp TSS_3408 TSS_3408

Gene      
Name: yhaV    Texpresso search in the literature
Synonym(s): ECK3118, G7629, b3130
Genome position(nucleotides): 3277337 --> 3277801
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 43.87
External database links:  
ASAP:
 ABE-0010289
ECHOBASE:
 EB2614
ECOLIHUB:
 yhaV
OU-MICROARRAY:
 b3130
STRING:
 511145.b3130
COLOMBOS: yhaV


Product      
Name: ribosome-dependent mRNA interferase toxin YhaV
Synonym(s): YhaV, ribonuclease toxin YhaV
Sequence: Get amino acid sequence Fasta Format
Molecular weight: 17.836
Isoelectric point: 9.706
Motif(s):
 
Type Positions Sequence Comment
12 -> 150 LYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKNKDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRET
85 -> 94 RVKFGAGRYR UniProt: Complete loss of toxicity..
94 -> 94 R UniProt: Partial loss of toxicity..

 
Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.2 - RNA related --> 2.2.4 - RNA degradation
Gene Ontology Terms (GO)  
cellular_component GO:0110001 - toxin-antitoxin complex
molecular_function GO:0004518 - nuclease activity
GO:0004519 - endonuclease activity
GO:0005515 - protein binding
GO:0016787 - hydrolase activity
GO:0004540 - ribonuclease activity
GO:0004521 - endoribonuclease activity
GO:0042803 - protein homodimerization activity
GO:0043023 - ribosomal large subunit binding
biological_process GO:0006355 - regulation of transcription, DNA-templated
GO:0006402 - mRNA catabolic process
GO:0040008 - regulation of growth
GO:0030308 - negative regulation of cell growth
GO:0044010 - single-species biofilm formation
GO:0090501 - RNA phosphodiester bond hydrolysis
GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic
Note(s): Note(s): ...[more].
Reference(s): [1] Coles M., et al., 2005
External database links:  
ALPHAFOLD:
 P64594
ECOCYC:
 G7629-MONOMER
ECOLIWIKI:
 b3130
INTERPRO:
 IPR021679
PFAM:
 PF11663
PRIDE:
 P64594
REFSEQ:
 NP_417599
SMR:
 P64594
UNIPROT:
 P64594


Operon      
Name: prlF-yhaV         
Operon arrangement:
Transcription unit        Promoter
sohA-yhaV


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3408 3276940 forward nd [RS-EPT-CBR] [2]
  promoter TSS_3410 (cluster) 3278324 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Coles M., Djuranovic S., Soding J., Frickey T., Koretke K., Truffault V., Martin J., Lupas AN., 2005, AbrB-like transcription factors assume a swapped hairpin fold that is evolutionarily related to double-psi beta barrels., Structure 13(6):919-28

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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