Gene
Name:	deoB
Synonym(s):	ECK4375, EG10220, b4383, drm, thyR, tlr
Genome position(nucleotides):	4619603 --> 4620826 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	54.33
External database links:

ASAP:	ABE-0014377
CGSC:	867
ECHOBASE:	EB0216
ECOLIHUB:	deoB
OU-MICROARRAY:	b4383
STRING:	511145.b4383
COLOMBOS:	deoB

Transcriptional Regulation
	Display Regulation
Activated by:	CRP, Fis
Repressed by:	CRP, DeoR, ModE, CytR

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_5166 (cluster)	4619576	forward	nd	[RS-EPT-CBR]	[24]
promoter	TSS_5167	4619991	forward	nd	[RS-EPT-CBR]	[24]
promoter	TSS_5168	4620783	forward	nd	[RS-EPT-CBR]	[24]
promoter	TSS_5169	4620785	forward	nd	[RS-EPT-CBR]	[24]
promoter	TSS_5170	4620789	forward	nd	[RS-EPT-CBR]	[24]
promoter	TSS_5171	4621110	forward	nd	[RS-EPT-CBR]	[24]

Reference(s)
[1] Ahmad SI., Eisenstark A., 1979, Thymidine sensitivity of certain strains of Escherichia coli K12., Mol Gen Genet 172(2):229-31
[2] Ahmad SI., Pritchard RH., 1969, A map of four genes specifying enzymes involved in catabolism of nucleosides and deoxynucleosides in Escherichia coli., Mol Gen Genet 104(4):351-9
[3] Albrechtsen H., Ahmad SI., 1980, Regulation of the synthesis of nucleoside catabolic enzymes in Escherichia coli: further analysis of a deo Oc mutant strain., Mol Gen Genet 179(2):457-60
[4] Bonney RJ., Weinfeld H., 1971, Regulation of thymidine metabolism in Escherichia coli K-12: evidence that at least two operons control the degradation of thymidine., J Bacteriol 105(3):940-6
[5] Bonney RJ., Weinfeld H., 1971, Regulation of thymidine metabolism in Escherichia coli K-12: studies on the inducer and the coordinateness of induction of the enzymes., J Bacteriol 106(3):812-8
[6] Breitman TR., Bradford RM., 1968, Inability of low thymine-requiring mutants of Escherichia coli lacking phosphodeoxyribomutase to be induced for deoxythymidine phosphorylase and deoxyriboaldolase., J Bacteriol 95(6):2434-5
[7] Buxton RS., Hammer-Jespersen K., Hansen TD., 1978, Insertion of bacteriophage lambda into the deo operon of Escherichia coli K-12 and isolation of plaque-forming lambdadeo+ transducing bacteriophages., J Bacteriol 136(2):668-81
[8] Fateev IV., Antonov KV., Konstantinova ID., Muravyova TI., Seela F., Esipov RS., Miroshnikov AI., Mikhailopulo IA., 2014, The chemoenzymatic synthesis of clofarabine and related 2'-deoxyfluoroarabinosyl nucleosides: the electronic and stereochemical factors determining substrate recognition by E. coli nucleoside phosphorylases., Beilstein J Org Chem 10:1657-69
[9] Fischer M., Short SA., 1982, The cloning of the Escherichia coli K-12 deoxyribonucleoside operon., Gene 17(3):291-8
[10] Hammer-Jespersen K., Nygaard P., 1976, Multiple regulation of nucleoside catabolizing enzymes in Escherichia coli: effects of 3:5' cyclic AMP and CRP protein., Mol Gen Genet 148(1):49-55
[11] Hove-Jensen B., Rosenkrantz TJ., Haldimann A., Wanner BL., 2003, Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways., J Bacteriol 185(9):2793-801
[12] Sangurdekar DP., Zhang Z., Khodursky AB., 2011, The association of DNA damage response and nucleotide level modulation with the antibacterial mechanism of the anti-folate drug trimethoprim., BMC Genomics 12:583
[13] Skladnev DA., Sukhodolets VV., Mironov AS., 1978, [Regulation of the activity of Escherichia coli deo-operon structural genes: the mutation mapped within the operon boundaries and affecting drm and pup gene activity]., Genetika 14(12):2091-101
[14] Sukhodolets VV., 1999, [Formation of the heterozygous tandem duplication in the process of conjugation recombination in Escherichia coli: study of the effect of mutations for the recQ, uvrD, and recJ genes]., Genetika 35(4):450-8
[15] Sukhodolets VV., 2000, [Homologous recombination between direct repeats of chromosomal segments comprising heterozygotic duplications in Escherichia coli]., Genetika 36(6):758-66
[16] Sukhodolets VV., 2002, [Effect of mutations for the ruvABC genes on recombination between direct DNA repairs in Escherichia coli strains carrying extended tandem duplication]., Genetika 38(9):1215-22
[17] Sukhodolets VV., 1997, [Genetic study of the mechanism of tandem duplication formation in conjugational crosses in Escherichia coli K-12]., Genetika 33(11):1487-93
[18] Sukhodolets VV., 1998, [Further genetic study of tandem duplication formation in the region of the deo operon in the process of Escherichia coli K-12 conjugational recombination]., Genetika 34(10):1338-44
[19] Sukhodolets VV., Botina SG., Trenina MA., Ukhabotina LS., 2001, [Homologous recombination and chromosomal rearrangements in Escherichia coli strains carrying a heterozygous tandem duplication]., Genetika 37(5):591-601
[20] Sukhodolets VV., Dukhii DE., 1996, [Unequal crossing over in Escherichia coli: genetic and physical mapping of duplications isolated in conjugational matings]., Genetika 32(1):42-52
[21] Sukhodolets VV., Prokop'ev VV., 2005, [Unequal genetic exchange in Escherichia coli tandem duplications may represent a special pathway of homologous recombination]., Genetika 41(3):307-11
[22] Sukhodolets VV., Trenina MA., 2002, [Study of RecA-independent homologous recombination and a chromosomal rearrangement in the Escherichia coli strain carrying an extended tandem duplication]., Genetika 38(2):171-81
[23] Svenningsen BA., 1975, Regulated in vitro synthesis of the enzymes of the deo operon of Escerichia coli. properties of the DNA directed system., Mol Gen Genet 137(4):289-304
[24] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.