RegulonDB RegulonDB 11.1: Gene Form
   

gltP gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gltP yjcO nrfG nrfF gltPp1 gltPp1 gltPp6 gltPp6 gltPp8 gltPp8

Gene      
Name: gltP    Texpresso search in the literature
Synonym(s): ECK4070, EG10405, b4077
Genome position(nucleotides): 4294481 --> 4295794
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.27
Reference(s): [1] Tolner B., et al., 1992
[2] Wallace B., et al., 1990
External database links:  
ASAP:
 ABE-0013357
CGSC:
 34330
ECHOBASE:
 EB0400
ECOLIHUB:
 gltP
MIM:
 617105
OU-MICROARRAY:
 b4077
STRING:
 511145.b4077
COLOMBOS: gltP


Product      
Name: glutamate/aspartate : H+ symporter GltP
Synonym(s): GltII, GltP
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 47.159
Isoelectric point: 8.814
Motif(s):
 
Type Positions Sequence Comment
6 -> 26 FSLAWQILFAMVLGILLGSYL UniProt: Helical.
8 -> 411 LAWQILFAMVLGILLGSYLHYHSDSRDWLVVNLLSPAGDIFIHLIKMIVVPIVISTLVVGIAGVGDAKQLGRIGAKTIIYFEVITTVAIILGITLANVFQPGAGVDMSQLATVDISKYQSTTEAVQSSSHGIMGTILSLVPTNIVASMAKGEMLPIIFFSVLFGLGLSSLPATHREPLVTVFRSISETMFKVTHMVMRYAPVGVFALIAVTVANFGFSSLWPLAKLVLLVHFAILFFALVVLGIVARLCGLSVWILIRILKDELILAYSTASSESVLPRIIEKMEAYGAPVSITSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVIAKW
51 -> 71 LIKMIVVPIVISTLVVGIAGV UniProt: Helical.
85 -> 105 IIYFEVITTVAIILGITLANV UniProt: Helical.
160 -> 180 MLPIIFFSVLFGLGLSSLPAT UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.1 - glutamate
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.5 - aspartate
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015293 - symporter activity
GO:0022857 - transmembrane transporter activity
GO:0005280 - amino acid:proton symporter activity
biological_process GO:0006865 - amino acid transport
GO:0006835 - dicarboxylic acid transport
GO:0055085 - transmembrane transport
GO:0003333 - amino acid transmembrane transport
GO:1902600 - proton transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P21345
ECOCYC:
 GLTP-MONOMER
ECOLIWIKI:
 b4077
INTERPRO:
 IPR001991
INTERPRO:
 IPR018107
INTERPRO:
 IPR034703
INTERPRO:
 IPR036458
PANTHER:
 PTHR42865
PFAM:
 PF00375
PRIDE:
 P21345
PRODB:
 PRO_000022811
PROSITE:
 PS00713
PROSITE:
 PS00714
REFSEQ:
 NP_418501
SMR:
 P21345
UNIPROT:
 P21345


Operon      
Name: gltP         
Operon arrangement:
Transcription unit        Promoter
gltP


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter gltPp8 4294268 forward nd [COMP-AINF] [3]
  promoter gltPp6 4294307 forward nd [COMP-AINF] [3]
  promoter gltPp1 4294378 forward nd [COMP-AINF] [3]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Tolner B., Poolman B., Wallace B., Konings WN., 1992, Revised nucleotide sequence of the gltP gene, which encodes the proton-glutamate-aspartate transport protein of Escherichia coli K-12., J Bacteriol 174(7):2391-3

 [2] Wallace B., Yang YJ., Hong JS., Lum D., 1990, Cloning and sequencing of a gene encoding a glutamate and aspartate carrier of Escherichia coli K-12., J Bacteriol 172(6):3214-20

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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