RegulonDB RegulonDB 10.10: Gene Form
   

glpX gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

glpK glpX fpr GlpR GlpR MarA SoxS anti-anti-terminator anti-terminator terminator glpXp2 glpXp2 TSS_4623 TSS_4623 TSS_4622 TSS_4622 fprp fprp TSS_4621 TSS_4621

Gene      
Name: glpX    Texpresso search in the literature
Synonym(s): ECK3917, EG11517, b3925
Genome position(nucleotides): 4114569 <-- 4115579 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.78
External database links:  
ASAP:
 ABE-0012821
CGSC:
 30884
ECHOBASE:
 EB1479
ECOLIHUB:
 glpX
OU-MICROARRAY:
 b3925
STRING:
 511145.b3925
COLOMBOS: glpX


Product      
Name: fructose-1,6-bisphosphatase 2
Synonym(s): GlpX, fructose 1,6-bisphosphatase II
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 35.852
Isoelectric point: 5.13
Motif(s):
 
Type Positions Sequence
57 -> 57 E
88 -> 90 EGT
119 -> 119 Y
239 -> 239 K
29 -> 29 K

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0016787 - hydrolase activity
GO:0046872 - metal ion binding
GO:0042132 - fructose 1,6-bisphosphate 1-phosphatase activity
GO:0030145 - manganese ion binding
GO:0042803 - protein homodimerization activity
biological_process GO:0005975 - carbohydrate metabolic process
GO:0006071 - glycerol metabolic process
GO:0006094 - gluconeogenesis
GO:0016311 - dephosphorylation
GO:0030388 - fructose 1,6-bisphosphate metabolic process
External database links:  
ECOCYC:
 EG11517-MONOMER
ECOLIWIKI:
 B3925
INTERPRO:
 IPR004464
MODBASE:
 P0A9C9
PANTHER:
 PTHR30447
PDB:
 2R8T
PDB:
 3D1R
PDB:
 3BIH
PDB:
 3BIG
PDB:
 1NI9
PFAM:
 PF03320
PRIDE:
 P0A9C9
PRODB:
 PRO_000022800
REFSEQ:
 NP_418360
SMR:
 P0A9C9
UNIPROT:
 P0A9C9


Operon      
Name: glpFKX         
Operon arrangement:
Transcription unit        Promoter
glpFKX


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: GlpR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4621 4114497 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4622 4115212 forward nd [RS-EPT-CBR] [1]
  promoter TSS_4623 4115603 reverse nd [RS-EPT-CBR] [1]
  promoter glpXp2 4115606 reverse nd [ICWHO] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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