RegulonDB RegulonDB 10.6.3: Gene Form
   

aldA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

aldA gapC ydcF cybB ArcA ArcA ArcA DnaA FNR CRP ArcA ArcA SoxS Rob MarA cybBp6 cybBp6 cybBp7 cybBp7 cybBp5 cybBp5 TSS_1804 (cluster) TSS_1804 (cluster) TSS_1803 (cluster) TSS_1803 (cluster) aldAp aldAp

Gene      
Name: aldA    Texpresso search in the literature
Synonym(s): ECK1408, EG10035, ald, b1415
Genome position(nucleotides): 1488232 --> 1489671 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
50.97
External database links:  
ASAP:
ABE-0004725
CGSC:
17767
ECHOBASE:
EB0034
ECOCYC:
EG10035
ECOLIHUB:
aldA
OU-MICROARRAY:
b1415
REGULONDB:
b1415
STRING:
511145.b1415
M3D: aldA
COLOMBOS: aldA
PortEco: b1415


Product      
Name: aldehyde dehydrogenase A
Synonym(s): Ald, AldA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 52.273
Isoelectric point: 4.8
Motif(s):
 
Type Positions Sequence
207 -> 213 GRGETVG
2 -> 479 SVPVQHPMYIDGQFVTWRGDAWIDVVNPATEAVISRIPDGQAEDARKAIDAAERAQPEWEALPAIERASWLRKISAGIRERASEISALIVEEGGKIQQLAEVEVAFTADYIDYMAEWARRYEGEIIQSDRPGENILLFKRALGVTTGILPWNFPFFLIARKMAPALLTGNTIVIKPSEFTPNNAIAFAKIVDEIGLPRGVFNLVLGRGETVGQELAGNPKVAMVSMTGSVSAGEKIMATAAKNITKVCLELGGKAPAIVMDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQFVNRLGEAMQAVQFGNPAERNDIAMGPLINAAALERVEQKVARAVEEGARVAFGGKAVEGKGYYYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLEDAISMANDSDYGLTSSIYTQNLNVAMKAIKGLKFGETYINRENFEAMQGFHAGWRKSGIGGADGKHGLHEYLQTQVVYLQS
22 -> 475 AWIDVVNPATEAVISRIPDGQAEDARKAIDAAERAQPEWEALPAIERASWLRKISAGIRERASEISALIVEEGGKIQQLAEVEVAFTADYIDYMAEWARRYEGEIIQSDRPGENILLFKRALGVTTGILPWNFPFFLIARKMAPALLTGNTIVIKPSEFTPNNAIAFAKIVDEIGLPRGVFNLVLGRGETVGQELAGNPKVAMVSMTGSVSAGEKIMATAAKNITKVCLELGGKAPAIVMDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQFVNRLGEAMQAVQFGNPAERNDIAMGPLINAAALERVEQKVARAVEEGARVAFGGKAVEGKGYYYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLEDAISMANDSDYGLTSSIYTQNLNVAMKAIKGLKFGETYINRENFEAMQGFHAGWRKSGIGGADGKHGLHEYLQTQVV

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.23 - methylglyoxal metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0016491 - oxidoreductase activity
GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0004777 - succinate-semialdehyde dehydrogenase (NAD+) activity
GO:0008911 - lactaldehyde dehydrogenase activity
GO:0009013 - succinate-semialdehyde dehydrogenase [NAD(P)+] activity
GO:0050569 - glycolaldehyde dehydrogenase activity
GO:0042802 - identical protein binding
biological_process GO:0019301 - rhamnose catabolic process
GO:0042355 - L-fucose catabolic process
GO:0055114 - oxidation-reduction process
GO:0051289 - protein homotetramerization
Note(s): Note(s): ...[more].
Reference(s): [1] Alkim C., et al., 2015
External database links:  
DIP:
DIP-9081N
ECOCYC:
LACTALDDEHYDROG-MONOMER
ECOLIWIKI:
b1415
INTERPRO:
IPR016163
INTERPRO:
IPR029510
INTERPRO:
IPR016162
INTERPRO:
IPR016161
INTERPRO:
IPR016160
INTERPRO:
IPR015590
MINT:
MINT-1313045
MODBASE:
P25553
PDB:
2OPX
PDB:
2ILU
PDB:
2IMP
PDB:
2HG2
PFAM:
PF00171
PRIDE:
P25553
PRODB:
PRO_000022075
PROSITE:
PS00687
PROSITE:
PS00070
PROTEINMODELPORTAL:
P25553
REFSEQ:
NP_415933
SMR:
P25553
UNIPROT:
P25553


Operon      
Name: aldA         
Operon arrangement:
Transcription unit        Promoter
aldA


Transcriptional Regulation      
Display Regulation             
Activated by: MarA, CRP, SoxS, Rob
Repressed by: FNR, DnaA, ArcA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1803 (cluster) 1490746 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [2]
  promoter TSS_1804 (cluster) 1490754 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [2]
  promoter cybBp5 1490761 forward Similarity to the consensus
Read more >
[ICWHO] [3]
  promoter cybBp7 1490766 forward Similarity to the consensus
Read more >
[ICWHO] [3]
  promoter cybBp6 1490887 forward Similarity to the consensus
Read more >
[ICWHO] [3]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Alkim C., Cam Y., Trichez D., Auriol C., Spina L., Vax A., Bartolo F., Besse P., Francois JM., Walther T., 2015, Optimization of ethylene glycol production from (D)-xylose via a synthetic pathway implemented in Escherichia coli., Microb Cell Fact 14:127

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Mu¿¿iz-Rascado L, Garc¿¿a-Sotelo JS, Weiss V, Solano-Lira H, Mart¿¿nez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hern¿¿ndez S, Alquicira-Hern¿¿ndez K, L¿¿pez-Fuentes A, Porr¿¿n-Sotelo L, Huerta AM, Bonavides-Mart¿¿nez C, Balderas-Mart¿¿nez YI, Pannier L, Olvera M, Labastida A, Jim¿¿nez-Jacinto V, Vega-Alvarado L, Del Moral-Ch¿¿vez V, Hern¿¿ndez-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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