RegulonDB RegulonDB 10.9: Gene Form
   

argB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

argH argC argB TSS_4687 (cluster) TSS_4687 (cluster) argEp2 argEp2

Gene      
Name: argB    Texpresso search in the literature
Synonym(s): ECK3950, EG10064, b3959
Genome position(nucleotides): 4156013 --> 4156789 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
55.47
External database links:  
ASAP:
ABE-0012967
CGSC:
1020
ECHOBASE:
EB0062
ECOLIHUB:
argB
NCBI-GENE:
948464
OU-MICROARRAY:
b3959
STRING:
511145.b3959
COLOMBOS: argB


Product      
Name: acetylglutamate kinase
Synonym(s): ArgB
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 27.159
Isoelectric point: 5.321
Motif(s):
 
Type Positions Sequence
5 -> 235 LIIKLGGVLLDSEEALERLFSALVNYRESHQRPLVIVHGGGCVVDELMKGLNLPVKKKNGLRVTPADQIDIITGALAGTANKTLLAWAKKHQIAAVGLFLGDGDSVKVTQLDEELGHVGLAQPGSPKLINSLLENGYLPVVSSIGVTDEGQLMNVNADQAATALAATLGADLILLSDVSGILDGKGQRIAEMTAAKAEQLIEQGIITDGMIVKVNAALDAARTLGRPVDIA
44 -> 45 GG
66 -> 66 R
181 -> 186 DVSGIL
2 -> 258 MNPLIIKLGGVLLDSEEALERLFSALVNYRESHQRPLVIVHGGGCVVDELMKGLNLPVKKKNGLRVTPADQIDIITGALAGTANKTLLAWAKKHQIAAVGLFLGDGDSVKVTQLDEELGHVGLAQPGSPKLINSLLENGYLPVVSSIGVTDEGQLMNVNADQAATALAATLGADLILLSDVSGILDGKGQRIAEMTAAKAEQLIEQGIITDGMIVKVNAALDAARTLGRPVDIASWRHAEQLPALFNGMPMGTRILA

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.3 - arginine
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0016740 - transferase activity
GO:0016301 - kinase activity
GO:0003991 - acetylglutamate kinase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0042803 - protein homodimerization activity
GO:0034618 - arginine binding
biological_process GO:0006526 - arginine biosynthetic process
GO:0006974 - cellular response to DNA damage stimulus
GO:0008652 - cellular amino acid biosynthetic process
GO:0016310 - phosphorylation
GO:0042450 - arginine biosynthetic process via ornithine
External database links:  
DIP:
DIP-9136N
ECOCYC:
ACETYLGLUTKIN-MONOMER
ECOLIWIKI:
b3959
INTERPRO:
IPR041731
INTERPRO:
IPR037528
INTERPRO:
IPR001048
INTERPRO:
IPR004662
INTERPRO:
IPR036393
MODBASE:
P0A6C8
PDB:
2X2W
PDB:
2WXB
PDB:
1OHB
PDB:
1GS5
PDB:
1GSJ
PDB:
1OH9
PDB:
1OHA
PFAM:
PF00696
PRIDE:
P0A6C8
PRODB:
PRO_000022127
REFSEQ:
NP_418394
SMR:
P0A6C8
UNIPROT:
P0A6C8


Operon      
Name: argCBH         
Operon arrangement:
Transcription unit        Promoter
argCBH
argH


Transcriptional Regulation      
Display Regulation             
Repressed by: ArgR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4687 (cluster) 4157619 forward For this promoter, there
Read more >
[RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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