RegulonDB RegulonDB 10.8: Gene Form
   

aroP gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

aroP ampE pdhR tp2 ampD PdhR FNR CRP CRP CRP CRP CRP BtsR Cra BtsR CRP TyrR TyrR TSS_238 TSS_238 pdhRp pdhRp TSS_236 (cluster) TSS_236 (cluster) aroPp1 aroPp1 aroPp2 aroPp2 TSS_235 TSS_235 TSS_234 (cluster) TSS_234 (cluster) TSS_233 TSS_233

Gene      
Name: aroP    Texpresso search in the literature
Synonym(s): ECK0111, EG10084, aroR, b0112
Genome position(nucleotides): 120178 <-- 121551 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
52.69
External database links:  
ASAP:
ABE-0000384
CGSC:
998
ECHOBASE:
EB0082
OU-MICROARRAY:
b0112
PortEco:
aroP
STRING:
511145.b0112
COLOMBOS: aroP


Product      
Name: aromatic amino acid:H+ symporter AroP
Synonym(s): AroP, AroP phenylalanine/tyrosine/tryptophan APC transporter, AroR
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 49.69
Isoelectric point: 8.77
Motif(s):
 
Type Positions Sequence
118 -> 138 IQFWYPEIPTWVSAAVFFVVI
199 -> 199 G
424 -> 424 P
43 -> 63 SAGPGIILGYAIAGFIAFLIM
359 -> 379 FGLLMALVVSALVINWAMISL

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.13 - phenylalanine
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.14 - tyrosine
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0022857 - transmembrane transporter activity
GO:0005302 - L-tyrosine transmembrane transporter activity
GO:0015192 - L-phenylalanine transmembrane transporter activity
GO:0015196 - L-tryptophan transmembrane transporter activity
biological_process GO:0006865 - amino acid transport
GO:0015823 - phenylalanine transport
GO:0015827 - tryptophan transport
GO:0015828 - tyrosine transport
GO:0055085 - transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
AROP-MONOMER
ECOLIWIKI:
b0112
INTERPRO:
IPR004841
INTERPRO:
IPR004840
INTERPRO:
IPR002293
PANTHER:
PTHR11785
PFAM:
PF00324
PRIDE:
P15993
PRODB:
PRO_000022153
PROSITE:
PS00218
REFSEQ:
NP_414654
SMR:
P15993
UNIPROT:
P15993


Operon      
Name: aroP         
Operon arrangement:
Transcription unit        Promoter
aroP
aroP


Transcriptional Regulation      
Display Regulation             
Activated by: Cra
Repressed by: TyrR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_233 120916 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_234 (cluster) 120919 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_235 120955 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_236 (cluster) 121676 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_238 122852 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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