RegulonDB RegulonDB 10.8: Gene Form
   

btuC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

btuC btuE ihfA terminator TSS_2004 TSS_2004 TSS_2003 TSS_2003 TSS_2002 TSS_2002 TSS_2001 TSS_2001 btuEp2 btuEp2 btuEp btuEp btuDp btuDp

Gene      
Name: btuC    Texpresso search in the literature
Synonym(s): ECK1709, EG10127, b1711
Genome position(nucleotides): 1794172 <-- 1795152 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
55.45
External database links:  
ASAP:
ABE-0005712
CGSC:
945
ECHOBASE:
EB0125
OU-MICROARRAY:
b1711
PortEco:
btuC
STRING:
511145.b1711
COLOMBOS: btuC


Product      
Name: vitamin B12 ABC transporter membrane subunit
Synonym(s): BtuC
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 34.949
Isoelectric point: 9.648
Motif(s):
 
Type Positions Sequence
11 -> 35 QNIRWLLCLSVLMLLALLLSLCAGE
57 -> 81 LPRTLAVLLVGAALAISGAVMQALF
305 -> 324 IGVVTATLGAPVFIWLLLKA
111 -> 112 QL
114 -> 138 NWALGLCAIAGALIITLILLRFARR

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.13 - cobalamin
  6 - cell structure --> 6.1 - membrane
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0043190 - ATP-binding cassette (ABC) transporter complex
molecular_function GO:0005515 - protein binding
GO:0015420 - ATPase-coupled vitamin B12 transmembrane transporter activity
GO:0022857 - transmembrane transporter activity
GO:0042802 - identical protein binding
GO:0090482 - vitamin transmembrane transporter activity
biological_process GO:0015889 - cobalamin transport
GO:0055085 - transmembrane transport
GO:0035461 - vitamin transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Cymer F., et al., 2013
External database links:  
DIP:
DIP-9233N
ECOCYC:
BTUC-MONOMER
ECOLIWIKI:
b1711
INTERPRO:
IPR037294
INTERPRO:
IPR023691
INTERPRO:
IPR000522
MINT:
P06609
MODBASE:
P06609
PANTHER:
PTHR30472
PDB:
4FI3
PDB:
4R9U
PDB:
1L7V
PDB:
4DBL
PDB:
2QI9
PFAM:
PF01032
PRIDE:
P06609
PRODB:
PRO_000022235
REFSEQ:
NP_416226
SMR:
P06609
UNIPROT:
P06609


Operon      
Name: btuCED         
Operon arrangement:
Transcription unit        Promoter
btuD
btuE
btuE
btuCED


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2001 1794137 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2002 1794143 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2003 1795497 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2004 1795523 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Cymer F., von Heijne G., 2013, Cotranslational folding of membrane proteins probed by arrest-peptide-mediated force measurements., Proc Natl Acad Sci U S A 110(36):14640-5

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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