RegulonDB RegulonDB 10.8: Gene Form
   

clpP gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

tig clpX clpP anti-anti-terminator terminator anti-terminator TSS_583 TSS_583 TSS_582 TSS_582 TSS_581 TSS_581 TSS_580 TSS_580 clpXp clpXp TSS_578 TSS_578 TSS_577 (cluster) TSS_577 (cluster) TSS_576 TSS_576 clpPp2 clpPp2 TSS_575 TSS_575 clpPp3 clpPp3 TSS_573 TSS_573 TSS_572 TSS_572 clpPp1 clpPp1 TSS_570 TSS_570 TSS_569 (cluster) TSS_569 (cluster) TSS_568 TSS_568 TSS_567 TSS_567 TSS_566 TSS_566

Gene      
Name: clpP    Texpresso search in the literature
Synonym(s): ECK0431, EG10158, b0437, lopP
Genome position(nucleotides): 456677 --> 457300 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.12
External database links:  
ASAP:
 ABE-0001515
CGSC:
 31280
ECHOBASE:
 EB0156
MIM:
 614129
OU-MICROARRAY:
 b0437
PortEco:
 clpP
STRING:
 511145.b0437
COLOMBOS: clpP


Product      
Name: ATP-dependent Clp protease proteolytic subunit
Synonym(s): ClpP, LopP, heat shock protein F21.5
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 23.187
Isoelectric point: 5.614
Motif(s):
 
Type Positions Sequence
20 -> 20 V
33 -> 33 I
34 -> 34 Y
126 -> 126 F
15 -> 207 ALVPMVIEQTSRGERSFDIYSRLLKERVIFLTGQVEDHMANLIVAQMLFLEAENPEKDIYLYINSPGGVITAGMSIYDTMQFIKPDVSTICMGQAASMGAFLLTAGAKGKRFCLPNSRVMIHQPLGGYQGQATDIEIHAREILKVKGRMNELMALHTGQSLEQIERDTERDRFLSAPEAVEYGLVDSILTHRN

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.3 - proteins/peptides/glycopeptides
  2 - information transfer --> 2.3 - protein related --> 2.3.6 - turnover, degradation
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.4 - proteases, cleavage of compounds
  5 - cell processes --> 5.5 - adaptations --> 5.5.2 - temperature extremes
Gene Ontology Terms (GO)  
cellular_component GO:0009368 - endopeptidase Clp complex
GO:0005737 - cytoplasm
GO:0009376 - HslUV protease complex
molecular_function GO:0051117 - ATPase binding
GO:0005515 - protein binding
GO:0008233 - peptidase activity
GO:0016787 - hydrolase activity
GO:0004176 - ATP-dependent peptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0008236 - serine-type peptidase activity
GO:0042802 - identical protein binding
biological_process GO:0043068 - positive regulation of programmed cell death
GO:0006508 - proteolysis
GO:0006515 - protein quality control for misfolded or incompletely synthesized proteins
GO:0009266 - response to temperature stimulus
GO:0009408 - response to heat
GO:0009314 - response to radiation
GO:0010498 - proteasomal protein catabolic process
External database links:  
DIP:
 DIP-31838N
ECOCYC:
 EG10158-MONOMER
ECOLIWIKI:
 b0437
INTERPRO:
 IPR001907
INTERPRO:
 IPR033135
INTERPRO:
 IPR029045
INTERPRO:
 IPR023562
INTERPRO:
 IPR018215
MODBASE:
 P0A6G7
PANTHER:
 PTHR10381
PDB:
 1YG8
PDB:
 1TYF
PDB:
 1YG6
PDB:
 2FZS
PDB:
 3MT6
PDB:
 3HLN
PFAM:
 PF00574
PRIDE:
 P0A6G7
PRINTS:
 PR00127
PRODB:
 PRO_000022298
PROSITE:
 PS00382
PROSITE:
 PS00381
REFSEQ:
 NP_414971
SMR:
 P0A6G7
UNIPROT:
 P0A6G7


Operon      
Name: clpPX-lon         
Operon arrangement:
Transcription unit        Promoter
clpPX
clpPX
clpPX
clpX-lon
lon


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_566 455378 forward nd [RS-EPT-CBR] [1]
  promoter TSS_567 455382 forward nd [RS-EPT-CBR] [1]
  promoter TSS_568 455792 forward nd [RS-EPT-CBR] [1]
  promoter TSS_569 (cluster) 456551 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [1]
  promoter TSS_570 456560 forward nd [RS-EPT-CBR] [1]
  promoter TSS_572 456594 forward nd [RS-EPT-CBR] [1]
  promoter TSS_573 456597 forward nd [RS-EPT-CBR] [1]
  promoter TSS_575 456643 forward nd [RS-EPT-CBR] [1]
  promoter TSS_576 457052 forward nd [RS-EPT-CBR] [1]
  promoter TSS_577 (cluster) 457151 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [1]
  promoter TSS_578 457171 forward nd [RS-EPT-CBR] [1]
  promoter TSS_580 457296 forward nd [RS-EPT-CBR] [1]
  promoter TSS_581 458066 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_582 458197 forward nd [RS-EPT-CBR] [1]
  promoter TSS_583 458293 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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