RegulonDB RegulonDB 10.7: Gene Form
   

clpX gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

clpX clpP sraA terminator anti-terminator anti-anti-terminator TSS_585 TSS_585 TSS_584 TSS_584 TSS_583 TSS_583 TSS_582 TSS_582 TSS_581 TSS_581 TSS_580 TSS_580 clpXp clpXp TSS_578 TSS_578 TSS_577 (cluster) TSS_577 (cluster) TSS_576 TSS_576

Gene      
Name: clpX    Texpresso search in the literature
Synonym(s): ECK0432, EG10159, b0438, lopC
Genome position(nucleotides): 457426 --> 458700 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.53
External database links:  
ASAP:
 ABE-0001517
CGSC:
 31287
ECHOBASE:
 EB0157
OU-MICROARRAY:
 b0438
PORTECO:
 clpX
REGULONDB:
 b0438
STRING:
 511145.b0438
M3D: clpX
COLOMBOS: clpX
PortEco: b0438


Product      
Name: ATP-dependent Clp protease ATP-binding subunit ClpX
Synonym(s): ClpX, LopC
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 46.356
Isoelectric point: 5.003
Motif(s):
 
Type Positions Sequence
2 -> 424 TDKRKDGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVAPHRERSALPTPHEIRNHLDDYVIGQEQAKKVLAVAVYNHYKRLRNGDTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVISHRVETGSGIGFGATVKAKSDKASEGELLAQVEPEDLIKFGLIPEFIGRLPVVATLNELSEEALIQILKEPKNALTKQYQALFNLEGVDLEFRDEALDAIAKKAMARKTGARGLRSIVEAALLDTMYDLPSMEDVEKVVIDESVIDGQSKPLLIYGKPEAQQASGE
268 -> 274 IGFGATV
315 -> 318 NELS
317 -> 395 LSEEALIQILKEPKNALTKQYQALFNLEGVDLEFRDEALDAIAKKAMARKTGARGLRSIVEAALLDTMYDLPSMEDVEK
228 -> 230 RKH

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.3 - proteins/peptides/glycopeptides
  2 - information transfer --> 2.3 - protein related --> 2.3.4 - chaperoning, repair (refolding)
  2 - information transfer --> 2.3 - protein related --> 2.3.6 - turnover, degradation
Gene Ontology Terms (GO)  
cellular_component GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol
GO:0009376 - HslUV protease complex
molecular_function GO:0097718 - disordered domain specific binding
GO:0002020 - protease binding
GO:0005515 - protein binding
GO:0016887 - ATPase activity
GO:0046872 - metal ion binding
GO:0051082 - unfolded protein binding
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0004176 - ATP-dependent peptidase activity
GO:0008270 - zinc ion binding
GO:0042802 - identical protein binding
GO:0046983 - protein dimerization activity
biological_process GO:0030164 - protein denaturation
GO:0051301 - cell division
GO:0006457 - protein folding
GO:0006508 - proteolysis
GO:0030163 - protein catabolic process
GO:0016032 - viral process
GO:0043335 - protein unfolding
External database links:  
DIP:
 DIP-35907N
ECOCYC:
 EG10159-MONOMER
ECOLIWIKI:
 b0438
INTERPRO:
 IPR004487
INTERPRO:
 IPR003959
INTERPRO:
 IPR038366
INTERPRO:
 IPR010603
INTERPRO:
 IPR019489
INTERPRO:
 IPR027417
INTERPRO:
 IPR003593
MODBASE:
 P0A6H1
PANTHER:
 PTHR11262
PDB:
 4I9K
PDB:
 4I81
PDB:
 4I63
PDB:
 4I5O
PDB:
 4I4L
PDB:
 4I34
PDB:
 3HWS
PDB:
 3HTE
PDB:
 2DS8
PDB:
 2DS7
PDB:
 2DS6
PDB:
 2DS5
PDB:
 1OVX
PFAM:
 PF06689
PFAM:
 PF07724
PFAM:
 PF10431
PRIDE:
 P0A6H1
PRODB:
 PRO_000022300
PROTEINMODELPORTAL:
 P0A6H1
REFSEQ:
 NP_414972
SMART:
 SM00994
SMART:
 SM00382
SMART:
 SM01086
SMR:
 P0A6H1
SWISSMODEL:
 P0A6H1
UNIPROT:
 P0A6H1


Operon      
Name: clpPX-lon         
Operon arrangement:
Transcription unit        Promoter
clpPX
clpPX
clpPX
clpX-lon
lon


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_576 457052 forward nd [RS-EPT-CBR] [1]
  promoter TSS_577 (cluster) 457151 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [1]
  promoter TSS_578 457171 forward nd [RS-EPT-CBR] [1]
  promoter TSS_580 457296 forward nd [RS-EPT-CBR] [1]
  promoter TSS_581 458066 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_582 458197 forward nd [RS-EPT-CBR] [1]
  promoter TSS_583 458293 forward nd [RS-EPT-CBR] [1]
  promoter TSS_584 458768 forward nd [RS-EPT-CBR] [1]
  promoter TSS_585 458780 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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